Disease Models

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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Custom Gastroenterology & Hepatology Models

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At Ace Therapeutics, our goal is to advance research and accelerate new drug development for gastrointestinal (GI) and liver diseases. To achieve this, we have developed extensive expertise in customizing relevant preclinical models. A key strength is our ability to tailor these diverse model platforms to the specific needs of researchers and provide associated testing services. Whether you require organoids, genetically engineered animal models, or advanced microfluidic systems, we have the capabilities to support you.

Our Gastroenterology & Hepatology Models

Gastrointestinal Disease Models

Gastroesophageal Reflux Disease (GERD) Models
Gastric Ulcer Disease Models
Gastrointestinal Dysmotility Disease Models
Gastritis Disease Models
Duodenal Ulcer Disease Models
Appendicitis Disease Models
Crohn Disease Models
Intestinal Inflammation Disease Models
Intestinal Adhesive Disease Models
Irritable Bowel Syndrome (IBS) Disease Models

Liver Disease Models

Bile Accumulation Disease Models
Alcoholic Liver Disease Models
Hepatitis Disease Models
Fatty Liver Disease Models
Liver Fibrosis Disease Models
Cirrhosis Disease Models
Liver Failure Disease Models
Viral Hepatitis Disease Models
Autoimmune Liver Disease Models
Inherited Liver Disease Models

Biliary Disease Models

Cholecystitis Disease Models
Cholangitis Disease Models
Biliary Atresia Models
Gallstone Disease Models

Pancreatic Disease Models

Pancreatitis Disease Models
Pancreatic Microcirculation Disorder Disease Models

Other Digestive Disease Models

Esophageal Disease Models
Food Allergy Disease Models
Abdominal Infection Disease Models
Multiple Organ Failure Disease Models

What Gastroenterology & Hepatology Models Can We Develop?

Esophageal Disease Model Customization

Ace Therapeutic offers a full range of customizable esophageal disease modeling services. Using organoids and animal models, we can recreate esophageal tissue damage, motility dysfunction, bacterial overgrowth, and inflammatory responses associated with conditions like GERD and Barrett's esophagus. Our model systems can provide personalized insights and preclinical platforms for the development of novel diagnostics and therapeutics.

Gastrointestinal Disease Model Customization

At Ace Therapeutic, we have extensive capabilities for customizing preclinical gastrointestinal disease models. Through approaches like CRISPR genome editing, microbiome engineering and surgical techniques in rodents, we can replicate multiple disease factors such as genetic mutations, epithelial damage and microbial dysbiosis. We offer tailored solutions for disease research and drug development.

Liver Disease Model Customization

The Hepatology Research Division at Ace Therapeutic has created numerous preclinical liver disease models that are ideal for compound screening and in-depth molecular efficacy analysis. Our mission is to offer you comprehensive pharmacological data on your candidate compounds of interest, streamlining the drug development process. Moreover, we can establish correlations between the study of specific biomarkers and relevant parameters through histology and/or ELISA.

Biliary Disease Model Customization

Ace Therapeutic specializes in mouse models comorbid with primary sclerosing cholangitis and inflammatory bowel disease. Through genomic engineering, our models investigate how colitis impacts bile acid metabolism and liver cholestasis at molecular levels. Metabolomic analyses of bile, cholesterol, fat and fat-soluble vitamins allow assessment of candidate compounds' ability to treat biliary dysfunction and evaluate pathological linkages between the gut and liver.

Pancreatic Disease Model Customization

Ace Therapeutic specializes in customizing disease models to facilitate research on various aspects of pancreatic diseases, including protein misfolding, endoplasmic reticulum stress, autophagy abnormalities, and inflammatory signaling pathway abnormalities. With our expertise, we can support developing drugs that target the underlying causes, manage pain, preserve pancreatic function, and address associated comorbidities.

How to Order Our Disease Model Customization Services?

Discuss your specific research needs

Confirm customized quote

Draft agreement and detailed contract

Develop models and conduct tests

Deliver results

At Ace Therapeutic, our customized approach supports a wide range of research applications from target discovery to predictive efficacy testing. If you would like to partner with us to create breakthroughs in understanding and treating complex gastrointestinal and liver diseases, please feel free to contact us.

Our products and services are for research use only and can not be used for diagnostic or other purposes.