Ace Therapeutics is an expert in the field of liver disease model construction. Our technical team has more than ten years of research experience in the field of liver disease model construction and can provide you with the most scientific liver disease models.
Viral hepatitis B infection affects the health of more than 257 million people worldwide. Viral hepatitis B infection often leads to the progression of liver disease to diseases such as liver fibrosis, cirrhosis, and hepatocellular carcinoma. Despite the development of protective vaccines, many new hepatitis B virus infections continue to occur each year. Therefore, new treatments still need to be developed. We aim to facilitate hepatitis B virus research and therapy development by providing accurate and scientifically sound experimental models.
What Can We Do?
In vivo studies of hepatitis B virus infection are essential to investigate the mechanisms of chronic infection, study virus-host interactions, and develop new therapeutic approaches. We have developed a series of methods to construct hepatitis B virus models, aiming to advance the study of hepatitis B virus.
- Non-Human Primate Models of Hepatitis B Virus Infection
Non-human primates are the most commonly used experimental models for studying hepatitis virus infection. We can provide different non-human primates to meet different research needs.
- As a non-human primate model fully sensitive to the human hepatitis B virus, we have established acute and chronic models of hepatitis B virus infection.
- We have also established small non-human primate models of hepatitis B virus infection, such as cynomolgus and rhesus macaques, to meet the needs of different investigators.
- Mouse Models of Hepatitis B Virus Infection
Mice are the most commonly used experimental animals. Therefore, we provide different types of mouse models of hepatitis B virus infection to simulate the process of viral infection.
- We have established methods for transgenic mouse models expressing different hepatitis B virus proteins, such as HBsAg, HBeAg, HBx, or the whole hepatitis B virus genome.
- We have established methods for using viral vectors to mediate hepatitis B virus transduction in mouse models.
- We have established methods to deliver the HBV genome into mice by hydrodynamic tail vein injection.
- We have established a hepatitis B virus model in human liver chimeric mice.
- We have established a hepatitis B virus model in dually engrafted mice.
- Other Models of Hepatitis B Virus Infection
In addition to non-human primate and mouse models, we can also provide other animal models that can be used to study hepatitis B virus infection.
- We have used different species of groundhogs to establish different types of hepatitis B virus infection models. In particular, the development rate and progression of the chronic infection model are very similar to the infection process in humans.
- We have also established the duck models of hepatitis B virus infection for the study of viral replication and the development of antiviral drugs.
- We have established models of hepatitis B virus infection in tree shrews to simulate the pathological course of the acute and chronic progression of the infection.
Ace Therapeutics has extensive hands-on experience in the field of hepatitis B virus model construction. If you would like to learn more about our services, please feel free to contact us.
Reference
- Liu, Y., et al., Animal models of hepatitis b virus infection-success, challenges, and future directions. Viruses, 2021. 13(5).
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