As experts in developing preclinical disease models, the scientists at Ace Therapeutics have extensive experience in customizing in vitro and in vivo disease models of gastric ulcer. Our expertise allows us to provide comprehensive disease pathology research and drug development services to our customers. Using advanced techniques and methodologies, we can accurately mimic the development of gastric ulcers and study factors such as mucosal damage, inflammation, and dysregulation of acid secretion.
What Is Gastric Ulcer?
Gastric ulcer refers to a sore or erosion that forms in the lining of the stomach. It is often caused by factors such as Helicobacter pylori infection, chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs), or gastric acid hypersecretion. Gastric ulcers can lead to abdominal pain, bloating, and indigestion. In severe cases, they may result in complications such as bleeding or perforation.
Figure 1. The occurrence and healing of gastric ulcers (Tarnawski A.S., Ahluwalia A., 2021)
How Do We Customize Gastric Ulcer Models?
Animal Species Selection
Animal Model Construction
Animal Model Validation
Our gastric ulcer model customization begins with selecting appropriate animal species based on research goals and physiological relevance. Options include:
- Rodents: Rats and mice, commonly used for small-scale studies and drug screening.
- Large Animals: Pigs or other large mammals, providing closer anatomical and physiological similarity to humans for translational research.
We employ various methods to induce gastric ulcers in the chosen animal species:
- Chemical Induction: Using nonsteroidal anti-inflammatory drugs (NSAIDs) like indomethacin or ethanol administration to disrupt gastric mucosal integrity and induce ulcers.
- Surgical Procedures: Techniques such as pyloric ligation, which creates a physical obstruction leading to increased gastric acid exposure and ulcer formation.
- Genetic Manipulation: Utilizing genetically modified animals with targeted mutations related to ulcer development pathways for mechanistic studies.
We can use a range of detection indicators and assessment methods to verify gastric ulcer models.
- Endoscopic Evaluation: Visualizing ulcer formation, size, and location using endoscopic techniques for real-time monitoring.
- Histological Analysis: Examining tissue samples for mucosal damage, inflammatory cell infiltration, and ulcer characteristics under microscopy.
- Gastric Acid Secretion Measurement: Assessing acid production using techniques like gastric pH monitoring or gastric acid aspiration tests.
- Inflammatory Marker Analysis: Quantifying cytokines, chemokines, and other inflammatory mediators in gastric tissue or blood samples to evaluate the inflammatory response.
What Can We Do for Gastric Ulcer Research?
Our gastric ulcer model customization service enables comprehensive basic pathology research in gastroenterology, allowing for in-depth studies of ulcer mechanisms, inflammatory responses, tissue damage progression, and genetic factors influencing ulcer development. We can help researchers investigate the cellular and molecular pathways involved in gastric ulcer formation, facilitating a better understanding of disease progression and potential therapeutic targets.
We leverage our customized disease models to help customers identify novel therapeutic targets and pathways that play key roles in ulcer healing, acid suppression, anti-inflammatory effects, and mucosal protection. Through mechanistic investigations and biomarker discovery, we uncover potential drug targets that can be further explored for developing innovative treatments targeting specific pathology of gastric ulcer.
- Pharmacodynamic & Pharmacokinetic Evaluation
Our gastric ulcer model customization service plays a crucial role in our customers' drug development endeavors by providing a robust platform for evaluating potential therapeutic interventions. We conduct comprehensive pharmacodynamic and pharmacokinetic evaluations, providing valuable insights into drug bioavailability, tissue distribution, and clearance rates.
Ace Therapeutics offers unparalleled gastric ulcer model customization services designed to meet the diverse research and drug development needs of our customers. With meticulous attention to detail, we tailor animal models to mimic gastric ulcer pathology, providing a robust platform for gastric ulcer pathology research and drug development. Contact us today to explore how our services can support and enhance your gastroenterology research endeavors.
Reference
- Tarnawski A.S., Ahluwalia A. The critical role of growth factors in gastric ulcer healing: The cellular and molecular mechanisms and potential clinical implications. Cells. 2021, 10(8):1964.
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