Ace Therapeutics provides customized preclinical models for pancreatic diseases. As a contract service provider with extensive expertise in disease modeling, we offer comprehensive services for designing and implementing pancreatic disease models. By leveraging deep insights into disease pathways coupled with expertise in stem cell biology, genomics and animal modeling methods, we provide personalized model solutions to meet specific research needs and accelerate target identification and efficacy testing.
What Pancreatic Diseases Can We Model?
The pancreas plays vital roles in digestion and metabolism through enzymes and hormones like insulin. Our research focuses on modeling key pancreatic diseases and disorders.
- Pancreatitis: We investigate both acute and chronic forms using in vitro and in vivo approaches. This allows the study of the mechanisms driving pancreatic cell inflammation and damage as well as dysregulated zymogen activation pathways.
- Pancreatic microcirculatory disorders: We specially focus on understanding how microvascular flow in the pancreas impacts organ function. This includes modeling conditions such as hemorrhagic pancreatitis linked to microvascular injury, ischemia from reduced blood supply, and vascular abnormalities tied to chronic pancreatitis.
What Types of Pancreatic Disease Models Can We Customize?
- In Vitro Pancreatic Disease Model Customization
Cell-Based Models
Pancreatic Organoids
Pancreas-on-Chip
- We specialize in the growth and maintenance of pancreatic cells using controlled laboratory conditions, ensuring optimal cell health and viability.
- Through the utilization of biomaterial scaffolds and growth factors, we can differentiate pluripotent stem cells into pancreatic progenitors and specialized lineages such as acinar or ductal cells.
- Multicellular cultures incorporating pancreatic and supportive immune or stromal cells are developed using our methods to replicate the complex tissue microenvironment.
- Our expertise extends to manipulating pancreatic cell lines or primary cells through genetic modification techniques. This enables the introduction of disease-specific mutations or alterations for studying specific diseases or conditions.
- By carefully controlling culture conditions and providing specific growth factors, our pancreatic organoids can self-organize and form structures similar to miniature pancreatic tissue and maintain functional characteristics, including the production of digestive enzymes, hormones such as insulin and glucagon secretion and response to stimulation.
- Microfluidic organ-chip platforms recreate native tissue architecture and cell-cell interactions in a dynamic microenvironment. For example, we can model the acinus functional unit containing acinar, stellate and endothelial cells.
- In Vivo Pancreatic Disease Model Customization
Animal Species
Modeling methods
- Mice, rats, pigs, non-human primates, lagomorphs.
- Xenograft Models: We have expertise implanting human pancreatic tumor cell lines and patient tumor samples into immunodeficient mice to evaluate novel anti-cancer compounds and elucidate metastasis mechanisms.
- Genetically Engineered Models: Through CRISPR/Cas9 editing and transgenic techniques, we develop custom mouse lines expressing disease-linked mutations to advance understanding of molecular pathogenesis.
- Orthotopic Implantation Models: Leveraging surgical skills, we orthotopically engraft pancreatic tumors into mice to recapitulate the native microenvironment for preclinical studies of treatments.
- Chemically Induced Disease Models: Employing toxicology expertise, our team induces pancreatitis, cancer and other conditions in rodents using known triggers to test therapeutic interventions and investigate progressive disease processes.
What Can We Do for Preclinical Pancreatic Disease Research?
- Pancreatic Disease Drug Development
Ace Therapeutics leverages customized disease models to support the preclinical evaluation of therapies for pancreatic cancer, pancreatitis, diabetes and other disorders. In vitro models enable personalized testing, while animal models allow efficacy and safety assessments of compounds such as small molecules, biologics and targeted therapies.
- Pancreatic Disease Mechanism Studies
Our tailored pancreatic organoids and genetically engineered mouse models allow us to help customers investigate the initiation, progression, and molecular pathways of pancreatic diseases. By delving into these fundamental aspects, we contribute to a deeper understanding of disease mechanisms and the identification of potential therapeutic targets.
Highlights of Our Pancreatic Disease Models & Customization Services
- Genetically engineered mouse and cell models recapitulating common mutations in hereditary pancreatitis allow deeper study of disease pathogenesis and hereditary factors.
- Large animal models of acute pancreatitis through blockade of pancreatic ducts closely mimic human anatomical complexities for probes of microcirculatory dysfunction.
- Our service covers a wide range of pancreatic diseases and provides a one-stop-platform for assessing the efficacy and safety of potential therapeutics, accelerating the drug development process.
If you need a partner with advanced pancreatic modeling solutions to drive your discovery and development goals, please contact Ace Therapeutics to inquire about our customized disease modeling services today. Our experience will help propel your research forward.
Related Products
 |
- Mouse Pancreatic Organoid Culture Medium
- Human Pancreatic Organoid Culture Medium
|
Inquiry |
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
