Ace Therapeutics excels at customizing disease models for cutting-edge research in gastroenterology and hepatology. Our services encompass disease pathology studies and drug development initiatives, providing comprehensive solutions to our customers' research needs. By leveraging advanced techniques and methodologies, we can create tailored models that mimic ulcer development, mucosal damage, inflammation, and acid secretion dysregulation, allowing researchers and pharmaceutical companies to gain invaluable insights into the pathology of this condition and develop novel treatment strategies.
What is Duodenal Ulcer?
Duodenal ulcer is a type of peptic ulcer that forms in the lining of the duodenum, the first part of the small intestine. It typically results from an imbalance between digestive fluids, stomach acid, and protective mucosal barriers, leading to mucosal erosion and ulceration.
Figure 1. Cysteamine-induced duodenal ulcer in rats (Khomenko T., et al., 2014)
How Do We Customize Duodenal Ulcer Models?
Animal Species Selection
Duodenal Ulcer Induction Methods
- Rodent models (mice, rats) are the most commonly used animals.
- Large species models (e.g. rabbits, pigs) can also be developed but require more lead time and resources.
- Chemical Agents: Administering cysteamine, indomethacin, or other irritants to disrupt mucosal integrity and induce ulcer formation.
- Animal Surgical Procedures: Performing duodenal ligation, mucosal injury, or ischemia-reperfusion procedures to simulate ulcer development.
- Genetic Modifications: Creating genetically modified animal models with targeted mutations related to the pathogenesis of duodenal ulcer.
What Can We Do for Duodenal Ulcer Research?
- Pathology Research of Duodenal Ulcer
Ace Therapeutics offers comprehensive services for pathological research using customized duodenal ulcer models. Our expertise includes histological analysis to evaluate ulcer characteristics, mucosal damage, and inflammatory responses. We also conduct acid secretion assessments and inflammatory marker analysis, providing valuable insights into duodenal ulcer disease mechanisms.
- Drug Development Services
Through customized duodenal ulcer models, we enable efficient preclinical testing and screening of potential drug candidates, evaluating their efficacy and safety in a controlled environment.
- Efficacy Testing: Evaluating potential therapeutic interventions, including drugs targeting ulcer healing, acid suppression, anti-inflammatory effects, and mucosal protection.
- Pharmacokinetics/Pharmacodynamics: Assessing drug absorption, distribution, metabolism, and treatment effects on ulcer healing processes.
- Safety Profiling: Investigating potential adverse effects, toxicity, and safety profiles of candidate drugs in duodenal ulcer models.
Our Techniques & Platforms for Duodenal Ulcer Model Customization
| Techniques & Platforms |
Examples |
Applications |
| Endoscopic Evaluation |
Endoscopy |
Real-time visualization and assessment of ulcer formation, size, and location. |
| Histological Analysis |
Histopathological examinations |
Studies of ulcer characteristics, mucosal damage, and inflammatory responses. |
| Functional Studies |
Motility studies, duodenal mucosal barrier function testing, and molecular assays |
Investigation of the underlying mechanisms and treatment responses. |
| Imaging Techniques |
MRI, CT scans, ultrasound, bioluminescence |
Non-invasive assessment and monitoring of ulcer progression. |
| Genome Editing |
CRISPR/Cas9 |
Creation of knockouts and transgenic animals. |
| Biomarker Analysis |
IHC, qPCR, ELISA, LC-MS |
Identification of biomarkers associated with ulcer severity and treatment response. |
Ace Therapeutics' duodenal ulcer model customization services are designed to meet customers' research needs in gastroenterology. Our comprehensive approach includes precise ulcer induction methods, detailed pathological assessments, functional studies, and advanced imaging techniques. We offer customized solutions tailored to your specific research objectives, providing valuable insights into duodenal ulcer pathogenesis and therapeutic interventions. Contact us today to explore how we can support your research endeavors.
References
- Khomenko T., et al. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration. Dig Dis Sci. 2014, 59(2):297-306.
- Song H., et al. Traditional chinese medicine prescription huang-qi-jian-zhong-tang ameliorates indomethacin-induced duodenal ulcers in rats by affecting NF-κB and STAT signaling pathways. Biomed Pharmacother. 2022, 156:113866.
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
