Ace Therapeutics aims to provide the most comprehensive and complete scientific research services for liver disease researchers worldwide. Based on our more than ten years of research experience, we will escort your research.
No single model can simulate all the pathological and physiological conditions of DILI. Therefore, building appropriate experimental models according to specific experimental needs is crucial for DILI research. We have extensive hands-on experience in the field of DlLI model building. Our scientists will build the most appropriate model for your needs to ensure the scientific accuracy of your study.
What Can We Do?
For different kinds of DILI, customized DILI experimental models are crucial as they are important tools for DILI research. We have developed a stable set of DILI modeling methods that can meet the different research needs of clients.
- Hepatocyte Models of DILI
The hepatocyte lineage models we offer mainly include primary hepatocytes and cell lines derived from hepatocellular carcinoma. Primary hepatocytes are considered to be the gold standard for establishing human-associated hepatocyte culture models. Cell lines from hepatocellular carcinoma are also widely used because they are easy to handle, phenotypically stable, and can multiply indefinitely. Our scientists will select the appropriate cell model for you based on your experimental protocol.
- Liver Tissue Engineering Models of DILI
We offer comprehensive liver tissue engineering model construction services to compensate for the inability of hepatocyte models to predict the hepatotoxicity of tested drugs. We do this by co-culturing primary hepatocytes with non-platelet cells to maintain their hepatocyte phenotype and viability over time. In addition, we can adjust the proliferation and differentiation time of pluripotent stem cells to obtain the desired liver tissue.
In vitro models, after all, cannot fully simulate the metabolic processes of drugs in the liver. Therefore, we offer different animal models for DILI to conduct in vivo studies of DILI. We offer different types of animal models, including mice, rats, rabbits, guinea pigs, pigs, sheep, monkeys, and other animals.
- Inflammation Models
We will build different inflammation models using substances commonly used to build inflammation models such as bacterial lipopolysaccharide, chlorpromazine, diclofenac, semiflurane, and amiodarone. We will determine the appropriate timing and mode of action according to specific experimental requirements in order to obtain the best modeling effect.
- Immune Tolerance Models
We constructed different immune tolerance models to meet the needs of different studies, such as the Pd-1-/--anti-CTLA4 mouse model and the Pd-1-/- mice model.
Ace Therapeutics has rich practical experience in the field of DILI model construction. Our scientists will customize the most scientific model construction scheme for you according to your experimental project to ensure the scientific validity and accuracy of your research. If you would like to learn more about our services, please feel free to contact us.
Reference
- McGill, M. R. Jaeschke, H. Animal models of drug-induced liver injury. Biochim Biophys Acta Mol Basis Dis. 2019. 1865(5): p. 1031-1039.
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Our products and services are for research use only and can not be used for diagnostic or other purposes.
