Ace Therapeutics aims to provide global customers with the liver disease models they need. In the field of genetic liver disease research, we have established uniform model generation standards and biological endpoints to ensure the reproducibility and scientific validity of different batches of models.
Currently, there is no effective therapy for genetic liver disease in the clinic. Based on our rich practical experience in experimental model modeling, we can construct an exclusive experimental model for your research project to facilitate the progress of genetic liver disease research.
What Can We Do?
In vitro and in vivo disease models are important tools to study the disease. Therefore, we provide different in vitro and in vivo model generation services for different genetic liver diseases, including but not limited to
- Cell Models of Genetic Liver Disease
We offer stem cell-derived hepatocyte-like cells and induced pluripotent stem cells for the construction of models of different genetic liver diseases.
- Animal Models of Hemochromatosis
We offer different animal models for hemochromatosis, such as the classic mouse model, Hfe–/– and Hjv–/– mice, and in one hemochromatosis-like mouse model (Smad4Alb/Alb mice).
- Animal Models of Wilson's Disease
Mice, rats, and zebrafish are commonly used to construct models of Wilson's disease, such as the Long-Evans Cinnamon rat, the inbred mouse models, and the Atp7B knockout mouse.
- Animal Models of Alpha-1 Antitrypsin Deficiency
Knockout or knockdown animal models are commonly used tools to study alpha-1 antitrypsin deficiency. We can construct α-1 antitrypsin deficiency animal models by RNAi, Morpholino, CRISPR-Cas9 and other technologies.
Ace Therapeutics has a professional team in the field of constructing experimental models of genetic liver diseases. We strictly control every step of production to ensure that we provide you with the best-quality experimental models. In addition to the common disease models of genetic liver diseases, we can customize the most appropriate model for your research project to meet your research needs. If you would like to learn more about our services, please feel free to contact us.
Reference
- Ranucci, G., et al., Wilson's disease: Prospective developments towards new therapies. World J Gastroenterol, 2017. 23(30): p. 5451-5456.
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
