At Ace Therapeutics, we specialize in developing animal models for pancreatic microcirculation research, providing researchers with powerful tools to study the intricate interplay between blood flow, inflammation, and disease progression. We offer a comprehensive service, from model selection and development to customized imaging protocols and data analysis, ensuring you have the ideal model to address your specific research questions.
Introduction to Pancreatic Microcirculation
Pancreatic microcirculation refers to the intricate network of small blood vessels within the pancreas that is crucial for its function and health. This microvascular system ensures the delivery of oxygen and nutrients to the pancreatic tissue, including both the exocrine and endocrine components, while also facilitating the removal of metabolic waste products. The microcirculation within the pancreas plays a significant role in regulating pancreatic secretion and maintaining the structural integrity of the organ. Disruptions in this delicate microvascular network can lead to tissue ischemia, inflammation, and fibrosis, contributing to conditions such as acute and chronic pancreatitis.
Figure 1. Pancreatic microcirculation profiles in spontaneously hypertensive rats (Liu M., et al., 2021)
How We Customize Animal Models to Study Pancreatic Microcirculation Profiles
- Genetically Engineered Models
We specialize in creating animals with precise genetic modifications to recapitulate human pancreatic diseases. These models encompass both knock-out and knock-in variations of genes that are pivotal in affecting pancreatic microcirculation. By using these genetically engineered models, researchers can gain profound insights into the genetic underpinnings of critical conditions such as pancreatic cancer, diabetes, and pancreatitis.
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Key Genes Related to Pancreatic Microcirculation |
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Our expertise includes the development of models in which diseases are induced to study their impact on the pancreatic microcirculation. We employ both chemical and surgical methods to induce conditions like diabetes, pancreatitis, and pancreatic cancer in our models. By using our disease models, researchers can observe the microcirculatory changes that accompany these conditions, aiding in the development of targeted therapeutic interventions.
- Isolated Perfused Pancreas Models
We provide isolated perfused pancreas models, which involve the meticulous extraction and perfusion of the pancreas in a controlled laboratory environment. Researchers can achieve a clearer and more precise understanding of pancreatic microcirculation with our ex vivo models, facilitating the study of microvascular dynamics and the testing of pharmaceutical compounds.
Our Platforms for Assessing Pancreatic Microcirculation Profiles
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| Genetic Engineering Tools |
We use CRISPR-Cas9 and other cutting-edge technologies to create precise genetic modifications in animal models. |
| Intravital Microscopy |
We utilize intravital microscopy for real-time visualization of microcirculation in living animals, providing detailed insights into blood flow dynamics. |
| Laser Doppler Flowmetry |
We employ laser doppler flowmetry to measure blood flow in specific areas of the pancreas, providing quantitative data on microvascular perfusion. |
| Magnetic Resonance Imaging (MRI) |
We leverage MRI to obtain detailed anatomical information about the pancreas and its vasculature, allowing visualization of microvascular structures and changes. |
| Positron Emission Tomography (PET) |
We utilize PET to assess blood flow and metabolic activity in the pancreas, providing insights into the functional aspects of the microcirculation. |
At Ace Therapeutics, our experts have extensive experience developing customized animal models and providing related services. With our tailored models, you can investigate the dynamics of blood flow, vascular permeability, and cellular interactions within the pancreatic microcirculation. Whether you're studying pancreatic ischemia, inflammation, or vascular disorders, our custom animal models can provide valuable insights. Contact us to discuss your unique requirements.
Reference
- Liu M.M., et al. Pancreatic microcirculation profiles in the progression of hypertension in spontaneously hypertensive rats. Am J Hypertens. 2021, 34(1):100-109.
Related Services
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