Ace Therapeutics focuses on providing comprehensive modeling solutions to advance liver disease research. With extensive experience in disease etiology and pathogenesis, our scientific team can design customized model systems tailored to specific research goals. Whether investigating pathogenic mechanisms, evaluating drug targets, or screening therapeutic candidates, Ace Therapeutics can develop the appropriate in vitro or in vivo model.
What Liver Diseases Can We Model?
What Types of Liver Disease Models Can We Customize?
- In Vitro Models of Liver Diseases
| Types |
Service Details |
| Cell-Based Models |
Ace Therapeutics has extensive experience constructing physiologically relevant cell-based systems using hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells, Kupffer cells and cholangiocytes alone and in defined combinations to model liver pathologies, allowing for investigations into disease progression, drug screening, and understanding the underlying molecular processes. |
| Liver Organoid Models |
We can customize liver organoids from different species, including human, mouse, and rat, which comprehensively recapitulate liver-specific conditions and provide valuable platforms for studying disease mechanisms and drug development. |
| Liver Tissue Slides |
Our expertise encompasses a diverse range of liver tissue slides, including those derived from different animal species and representing various disease types. By tailoring these tissue slides to specific research needs, we enable researchers to gain valuable insights into liver diseases, evaluate therapeutic interventions, and develop targeted treatments. |
- In Vivo Models of Liver Diseases
| Types of Models |
Model Details |
| Intrahepatic Bile Accumulation |
- α-Naphthylisothiocyanate model
- Taurine sodium cholate model
- Extrahepatic bile stasis model
|
| Alcoholic Liver Disease |
- Ethanol gavage plus high-fat feeding model
- Alcohol gavage model
- Lieber-Decarli model
- Tsukamoto-French model
|
| Hepatitis |
- Animal models of hepatitis induced by hepatotoxins or immune mediators
- Virus (HBV/HCV)-induced hepatitis animal model
|
| Fatty Liver |
- High-fat feed-induced fatty liver model
- Fatty liver model induced by feeding high-sugar feed after fasting
- Total parenteral nutrition-induced fatty liver model (TPN)
- Chemical substance-induced fatty liver model
- Alcoholic fatty liver model
- Special breed animal fatty liver model.
|
| Liver Fibrosis |
- Carbon tetrachloride-induced liver fibrosis animal model
- Animal model of liver fibrosis induced by dimethylnitrosamine (DMN)
- Thioacetamide (TAA)-induced liver fibrosis model
- Ethanol-induced liver fibrosis model
- Liver fibrosis model induced by the serum immunization method
- Common bile duct ligation-induced liver fibrosis model
|
| Liver Cirrhosis |
- Carbon tetrachloride-induced liver cirrhosis animal model
- Animal model of nutritional cirrhosis
- Ethanol-induced liver cirrhosis model
- Liver cirrhosis model induced by the serum immunization method
- Animal model of chemical-induced liver cirrhosis
- Liver cirrhosis model induced by common bile duct ligation
|
| Liver Failure |
- Animal model of liver failure induced by liver resection
- Animal model of liver failure induced by acute hepatic ischemia
- Carbon tetrachloride-induced liver failure model
- Acetaminophen-induced liver failure model
- Galactosamine-induced liver failure model
- Thioacetamide (TAA)-induced liver failure model
- Animal model of liver failure induced by multiple factors
|
What Can We Do for Preclinical Liver Disease Research?
- Hepatology Mechanism Research
At Ace Therapeutics, we provide specialized services by customizing liver disease models and conducting in-depth research on disease mechanisms. By tailoring our models to specific liver diseases, we enable researchers to gain valuable insights into the complex molecular pathways, cellular interactions, and key factors driving disease progression.
- Pharmacodynamic Evaluation of Liver Disease Drugs
Leveraging expertise in disease modeling and translational pharmacology, Ace Therapeutics provides customized liver platforms to evaluate novel therapeutic candidates. Our personalized in vitro or in vivo systems enable targeted investigations into drug candidates' mechanisms, efficacy, and properties.
- Drug Hepatotoxicity Studies
Ace Therapeutics offers tailored liver disease modeling services to support the rigorous hepatotoxicity evaluation of drug candidates. By generating customized organoid, cell-based and animal platforms reflective of disease factors, we enable robust assessments of toxicity potential, risk factors and safe dosing.
Ace Therapeutics offers researchers a powerful platform to study liver diseases, assess drug efficacy, and explore disease mechanisms. Contact us today to discuss how to leverage our customized liver disease modeling capabilities!
Related Products
 |
Liver Organoid Culture Medium |
- Liver Organoid Growth Medium (Human)
- Liver Organoid Growth Medium (Mouse)
|
Inquiry |
 |
Liver Tissue Slide |
- Liver Cirrhosis Tissue Slide
|
Inquiry |
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
