At Ace Therapeutics, we are dedicated to providing professional solutions for understanding and studying intestinal adhesions. Our team of expert scientists possesses extensive experience in developing reliable disease models that mimic the pathological characteristics of intestinal adhesion. These models are meticulously developed to support detailed disease mechanism research, enabling a deeper exploration of the underlying biological processes. Additionally, they serve as robust platforms for preclinical drug testing, facilitating the discovery and optimization of new therapeutic candidates.
What Is Intestinal Adhesion?
Intestinal adhesion refers to the abnormal attachment or fusion of adjacent intestinal loops, leading to the formation of scar tissue. Pathologically, adhesions are composed of a collagen-rich matrix that bridges the intestinal surfaces and restricts normal movement and flow. If severe, adhesions can lead to small bowel obstructions, chronic abdominal pain, and impaired function by disrupting the normal anatomical relationships in the abdominal cavity.
Figure 1. Abdominal adhesion tissue specimens and histologic adhesion rating scores from wild-type, JUN +/-, and JUN +/+ mice. (Foster D.S., et al., 2020)
How We Develop Disease Models of Intestinal Adhesion
| Animal Species |
Advantages |
| Rats and Mice |
- Small size, ease of handling, cost-effectiveness, well-characterized genetics, and availability of numerous biological tools and resources.
- Widely used in the initial stages of research.
|
| Rabbits |
- Larger abdominal cavity allows for more complex surgical procedures.
- Commonly used in studies requiring detailed anatomical and physiological observations.
|
| Non-Human Primates |
- Close genetic and physiological resemblance to humans.
- Used in advanced stages of research where human-like responses are crucial.
|
- Our Modeling Methods for Intestinal Adhesion
Surgical Animal Models
We perform minimally invasive (laparoscopic) surgery like cecal abrasion or serosal defect creation to mechanically perturb the intestinal lining and initiate the wound healing processes involved in adhesion formation.
Inflammation-Based Models
Leveraging our capabilities in the inflammatory response, we utilize microbial agents to trigger an inflammation that leads to the development of intestinal adhesions. Bacterial or viral pathogens can be introduced into the intestinal tract to simulate infection-related adhesion formation.
Biomaterials-Based Models
Biomaterials, such as films, meshes, or gels, can be used to simulate adhesion formation in animal models. These materials are placed or implanted in the abdominal cavity or between intestinal loops to induce adhesion.
Our R&D Services for Intestinal Adhesion
Using our customized intestinal adhesion models, we can offer in-depth studies into the underlying mechanisms of adhesion formation and provide a robust platform for the preclinical testing and development of new therapeutic agents.
Comprehensive Disease Mechanism Studies
Preclinical Drug Development
- Identifying key biological pathways and molecular interactions involved in adhesion formation and resolution.
- Analyzing the roles of different cell types, such as fibroblasts, immune cells, and endothelial cells, in the development of adhesions.
- Investigating the impact of specific genes and genetic variations on adhesion susceptibility and severity.
- Identifying critical inflammatory pathways and mediators involved in infection-related adhesions.
- Discovering new targets for therapeutic intervention to mitigate infection-induced adhesions.
- Evaluating the effectiveness of drugs and biological agents in preventing or reducing adhesion formation.
- Conducting comprehensive safety evaluations to identify potential side effects and toxicity of new treatments.
- Determining the optimal dosage and administration routes for maximum therapeutic benefit.
- Assessing the durability and long-term effectiveness of biomaterials in preventing adhesions.
Ace Therapeutics develops fully customized intestinal adhesion models to advance academic research and drug development. We support projects from exploratory studies to late-stage preclinical development. For more information on how our services can benefit your projects, please contact us to discuss your specific needs and objectives.
Reference
- Foster D.S., et al. Elucidating the fundamental fibrotic processes driving abdominal adhesion formation. Nat Commun. 2020, 11(1):4061.
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