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Preclinical Gastroenterology & Hepatology CRO Services
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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Vaccine R&D Services in Gastroenterology and Hepatology

Inquiry

Ace Therapeutics offers comprehensive support for vaccine development, empowering customers in their quest to create effective vaccines against gastrointestinal (GI) and liver diseases. Our services encompass standard immunogenicity studies, enabling the evaluation of vaccine candidates' immune responses. Leveraging our expertise in microbiology, immunology, and molecular biology, we provide guidance throughout the entire vaccine development process.

What Are Our Targets for Vaccine Development?

Bacteria in the gastrointestinal tract and liver

Pathogenic Bacteria

Through our proficiency in microbial pathogenesis and molecular interrogations of host-pathogen interactions, Ace Therapeutics is equipped to guide sponsors from target selection to immunogenicity studies. With a focus on notable bacteria like Clostridium difficile, Helicobacter pylori, Salmonella typhi, our dedicated team designs tailored vaccines to target pathogenic bacteria causing gastrointestinal and liver infections.

Viruses in the gastrointestinal tract and liver

Viruses

With expertise in virology, reverse vaccinology, and analytical testing, Ace Therapeutics offers multi-pronged assistance for designing and validating preventives against harmful enteric and blood-borne viruses, such as Hepatitis B and Hepatitis C. This includes in silico antigen prediction, viral protein expression, formulation studies, and preclinical immunogenicity and challenge evaluations to validate candidates' efficacy.

Parasites in the gastrointestinal tract and liver

Parasites

Ace Therapeutics offers comprehensive support for the design and testing of vaccines targeting harmful protozoan and helminth infections. Our capabilities include antigen identification, formulation optimization, assessment of immunogenicity and protective efficacy in preclinical infection models. Our goal is to accelerate the development of new prevention options for our customers to control diseases such as giardiasis, amebiasis and schistosomiasis.

Types of Vaccines We Can Develop

Protein Vaccine Development Nucleic Acid Vaccine Development

Antigen Vaccine Development

We have extensive experience in expressing and purifying pathogenic antigens and evaluating immunogenic epitopes, and can formulate delivery systems using vaccine adjuvants, nanoparticles and liposomes based on customer needs and sample characteristics.

Virus-Like Particle (VLP) Vaccine Development

Through our professional transfection expression system, we can help customers design and develop non-infectious nanoparticle components that mimic natural virus particles. These multimeric structures can induce the body to produce powerful neutralizing antibodies.

Glycoconjugate Vaccine Development

Our expertise in carbohydrate chemistry helps customers combine short oligosaccharides with immunogenic carrier proteins to generate T cell-dependent responses against bacterial infections.

DNA Vaccine Development

Our team specializes in the design of eukaryotic expression plasmids containing antigen consensus sequences. To help customers enhance the immunogenicity of these DNA vaccines, we can also develop various delivery methods.

mRNA Vaccine Development

Leveraging our advanced RNA engineering tools, we support clients in the development of various forms of mRNA vaccines, including unmodified, optimized or self-amplified transcripts. To ensure efficient delivery and translation in dendritic cells, we utilize excipients to stabilize the mRNA payload for efficient lymphatic transport.

Highlights of Our Vaccine Development Services

We possess multidisciplinary expertise in microbiology, immunology, and molecular biology and can comprehensively analyze pathogens, host immune responses, and vaccine-induced immunity, providing holistic solutions to vaccine development.
We excel at the identification and selection of key antigens from pathogenic bacteria, viruses, and parasites associated with GI/liver infections.
Our services span the entire vaccine development process, from antigen validation to potency assessment, providing thorough assistance at each stage.

Ace Therapeutics is a provider of comprehensive vaccine development services in the field of gastroenterology and hepatology. Leveraging expertise in relevant disease models and assay development, our scientists can generate the critical data needed to advance vaccine candidates. Contact us today to inquire about our vaccine development services and unlock new possibilities in combating these diseases.

Our products and services are for research use only and can not be used for diagnostic or other purposes.