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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

GI & Hepatic Targeted Drug Delivery System Development

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Ace Therapeutics is focused on offering comprehensive services in the development of delivery systems targeted to the unique physiological environment of the gastrointestinal (GI) tract and liver. Through our formulation expertise in areas such as particulate systems, bioadhesives and enzymatic triggers, we work to achieve site-specific and controlled release of a wide range of therapeutics. Our personalized development services help companies overcome delivery challenges and maximize the potential of candidates for gastrointestinal and hepatic diseases.

What Can We Do for the Development of Gastrointestinal & Hepatic Targeted Drug Delivery System?

	Gastric Targeted Drug Delivery System Development Leveraging its deep insight into gastric biology and comprehension of local environmental variables, Ace Therapeutics offers comprehensive support in formulation design, optimization, and characterization of oral dosage forms that specifically target the gastric region. We offer tailored solutions for improved drug bioavailability, controlled release, and enhanced therapeutic efficacy, ensuring precise delivery and absorption in the stomach.
	Intestine Targeted Drug Delivery System Development Through expertise in intestinal physiology and barriers to drug absorption within the small and large bowels, Ace Therapeutics is able to design innovative carrier systems based on customer needs to facilitate transcellular or transmembrane transport of therapeutics. Our formulation capabilities focus on targeted particle design, enteric coatings, and enzymatic prodrugs, ensuring the effective delivery of drugs to the intestinal region.
	Liver Targeted Drug Delivery System Development Ace Therapeutics provides comprehensive services for the development of liver-targeted drug delivery systems. We specialize in both passive and active targeting strategies for liver drug delivery, including hepatic parenchymal cell targeting, non-parenchymal cell targeting, and hepatic tumor cell targeting. Our services cover a wide range of delivery pathways, and we also provide pharmacokinetic studies to help customers optimize formulations and dosages in an all-round way.

Types of Targeted Drug Delivery Systems We Can Develop

Particulate Systems Coating & Prolonged Release Conjugates & Ligand-Targeted Novel Platforms

Liposomes for site-specific delivery of hydrophilic payloads to the small intestine/colon.
Biodegradable microparticles incorporating proteins/peptides for controlled gastric release.
Nanoparticles improve the oral bioavailability of poorly soluble drugs via lymphatic uptake.
Solid lipid nanoparticles protect thermosensitive compounds and enable intestinal absorption.

Enteric coatings provide intestinal-targeted release using pH-responsive polymers.
Capsule-in-capsule systems combine immediate and extended gastric retention.
Mucoadhesive/bioadhesive polymers for localized topical delivery to the stomach/intestinal lining.

Monoclonal antibody-chemotherapy conjugates actively targeted to select hepatic tumors.
Carbohydrate-coated carriers for endocytosis via macrophage mannose receptors in the liver.
Liposomal formulations integrated with bile acid salts for hepatocyte uptake and targeting.
Nanocarriers functionalized with transferrin/folate ligands enable receptor-mediated endocytosis.

Self-nanoemulsifying liquid and solid solutions improve the solubility and permeability of highly lipophilic molecules.
Microneedle arrays provide pain-free intradermal/subcutaneous implantation routes for prolonged delivery.
Cell-based vehicles such as exosomes ferry nucleic acid payloads across the intestinal epithelium.
Adenoviral and lentiviral vectors encoding therapeutic transgenes for local expression in the liver.

Highlights of Our Targeted Drug Delivery System Development Services

Multi-disciplinary team of formulation scientists, biologists, and analytical chemists.
Dedicated R&D center with formulation, analytics, and preclinical testing capabilities.
Extensive expertise in biology, physiology, and states of gastrointestinal and liver diseases.
Innovative formulation approaches using natural/synthetic polymers and lipids.
Comprehensive preclinical validation of formulations in biochemical, cell and animal models.

Are you in need of cutting-edge solutions for gastrointestinal & hepatic targeted drug delivery systems? Look no further than Ace Therapeutics. Our dedicated team of experts, advanced technology platform, and extensive expertise in gastrointestinal and liver targeting make us the ideal partner for your research and development needs. To discuss your project or request more information about our services, please contact us at your earliest convenience.

Our products and services are for research use only and can not be used for diagnostic or other purposes.