At Ace Therapeutics, our irritable bowel syndrome (IBS) model customization service is tailored to meet the specific needs of researchers and pharmaceutical companies. We utilize advanced techniques to create representative models that reflect the diverse symptoms and pathophysiology of IBS. By offering flexible and professional solutions, we help our customers efficiently explore novel therapeutic targets and develop potential treatments.
Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain, bloating, and altered bowel habits, such as diarrhea or constipation. Pathologically, IBS involves dysregulation of the gut-brain axis, visceral hypersensitivity, and changes in the gut microbiota. It often presents without a detectable organic cause, making its diagnosis and treatment challenging.
Figure 1. Mediators that may be involved in the pathology of irritable bowel syndrome (IBS) (Enck P., et al., 2016)
Process | Service Details |
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Animal Selection | We help you select the most appropriate animal species based on the research objectives and the specific aspects of IBS being studied. Commonly used animal species for IBS models include mice and rats. These species offer advantages such as their genetic tractability, availability of transgenic models, and the ability to induce IBS-like symptoms through stress or chemical treatments. |
Modeling Methods | Systemic Agents: Using drugs like dextran sulfate sodium (DSS) to induce gastrointestinal symptoms. Antibiotic Treatment: Disrupting gut microbiota balance to study its impact on IBS. Fecal Microbiota Transplantation: Introducing gut microbiota in IBS patients into germ-free or antibiotic-treated animals. Transgenic Animals: Developing genetically modified animals to study the role of specific genes in IBS. |
Intracolonic Irritants: Introducing chemicals such as mustard oil or capsaicin to induce inflammation and hypersensitivity.
Custom IBS Subtypes |
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Our customized IBS models at Ace Therapeutics are designed to provide comprehensive insights into the pathophysiology of IBS. By employing diverse modeling methods, selecting appropriate animal species, and accurately reflecting IBS classifications, we develop disease models tailored to our customers' specific research needs. If your organization seeks to gain new insights into IBS triggers and targets or accelerate the development of innovative treatments, please contact us.
Our products and services are for research use only and can not be used for diagnostic or other purposes.