Customized Rodent Models of Ocular Diseases

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Rodent ocular disease models have been widely used in the study of eye diseases because they have many similarities to humans. As one of the world's leading developers and suppliers of ocular disease models, Ace Therapeutics has successfully established an advanced rodent (rat/mouse) ocular disease model development platform to serve global scientific research and pharmaceutical companies. Here, you can get any rodent model you want for eye disease research to advance your projects.

Rodent Ocular Disease Models

Advantages of Rodent Models for Studying Ocular Diseases

Animal models are undoubtedly useful tools for understanding the mechanisms leading to ocular diseases and allowing for the testing of different treatments. Good animal models that map physiological or pathological states allow relatively transparent analysis of changes that occur in corresponding ocular diseases. Currently, researchers in the field of ophthalmology mainly focus on rodent models (rats, mice, etc.), due to the many similarities between rodents and humans, especially at the metabolic level. In addition, rodent ocular disease models have relatively low breeding costs, ease of reproduction, and the high availability of different research techniques, procedures, and results applied to these animals.

Fig. 1. mRNA isoforms in targeted and chemically induced Rpgrip1 murine models. (Krebs MP, et al., 2017)

Service Overview

As one of the world's leading developers and suppliers of ocular disease models, Ace Therapeutics has established an advanced rodent (rat/mouse) ocular disease model development platform, which is the ideal place to discover genetically determined hereditary eye variants and eye variant diseases caused by acquired physicochemical irritants. Here you can get any rodent model you want for eye disease research.

Explore Ace Therapeutics' Rodent Ocular Disease Models

Our talented scientists are always working to find and screen genetic mouse/mouse models and physicochemical stimuli models similar to human ocular diseases. With a comprehensive understanding of the mechanism and pathological manifestations of eye diseases, Ace Therapeutics can simulate human eye diseases by using genetic manipulation and various physical and chemical stimulation tools throughout the rodent model selection and development process. Please follow the links below for more detailed information of different rodent ocular disease models.

Importantly, we use a series of electroretinograms (ERGs), fundus photography, histology, etc., to characterize the resulting mutants and response groups, including genetic analysis and identification, immune and environmental factors, thus ensuring the most robust data and development of optimal rodent ocular disease models.

Advantages of Ace Therapeutics’ Rodent Ocular Disease Models

Rodent eye disease models cover a wide range of areas, including glaucoma, hereditary retinopathy, dry eye, etc.
High similarity to human ocular diseases
Low incidence of adverse reactions during the study
A series of supporting inspection services: ophthalmic pre-screening, and drug efficacy evaluation.
Customize models development services according to customer project needs.

Ace Therapeutics has the world's most advanced development platform for rodent ocular diseases. Our scientists will be by your side throughout the project. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

Monk C. Ocular Surface Disease in Rodents (Guinea Pigs, Mice, Rats, Chinchillas). Vet Clin North Am Exot Anim Pract. 2019 Jan;22(1):15-26.
Krebs MP, Collin GB, Hicks WL, et al. Mouse models of human ocular disease for translational research. PLoS One. 2017 Aug 31;12(8):e0183837.
Chang B, Hawes NL, Hurd RE, et al. Mouse models of ocular diseases. Vis Neurosci. 2005 Sep-Oct;22(5):587-93.

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