Customized Rodent Models of Experimental Autoimmune Uveitis

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Experimental autoimmune uveitis (EAU) models are achieved by provoking systemic immunity in animals. Ace Therapeutics provides our global customers with a well-established, robust, and reproducible modeling protocol to induce EUA models in rodents. With our extensive experience in the field of uveitis, you have reason to believe that we can help you overcome any difficulties in your research path, thus promoting the development of your project.

Rodent Models of Experimental Autoimmune Uveitis

What Is Experimental Autoimmune Uveitis?

Uveitis is an inflammatory disease that occurs primarily in the uveal tissues (iris, ciliary body, and choroid). Autoimmune or noninfectious uveitis is a vision-threatening condition of the neuroretina. Patients with autoimmune/noninfectious uveitis frequently exhibit an immune response against ocular antigens (Ags), such as retinal (retinal soluble antigen or [S-Ag]) and interphotoreceptor retinoid-binding protein (IRBP). Experimental autoimmune uveitis (EAU) is similar to key immunological features of human uveitis. It can be induced in susceptible rodents by retinal Ag immunization. It is an ideal animal model for studying human idiopathic uveitis and the treatment of ophthalmology products.

Fig. 1. Critical checkpoints in pathogenesis of uveitis. (Caspi RR, et al., 2011)

Service Overview

With an in-depth understanding of human uveitis pathogenesis, Ace Therapeutics is committed to providing global customers with high-standard model development and preclinical services for autoimmune uveitis research. We have a specialized research team to establish an experimental autoimmune uveitis (EAU) animal model that meets the research needs of our customers. These models are well-characterized, robust, and reproducible model that is easy to follow and quantify. It is an ideal model for you to evaluate drug treatment strategies.

Explore the Ace Therapeutics' Rodent Models of Experimental Autoimmune Uveitis

The key to the development of the EAU model is the selection of suitable susceptible rodent strains. At Ace Therapeutics, our expert team screens Lewis rats and B10.RIII as strains developed for experimental autoimmune uveitis. This is due to the monophasic course of the disease in Lewis rats, which develops into characteristic severe uveitis. Moreover, among IRBP-immunized mouse strains, the sensitivity level of B10.RIII mice were significantly higher than C57BL/6 mice. We offer the following two models of EAU to customers around the world.

Mouse Models of Experimental Autoimmune Uveitis
Rat Models of Experimental Autoimmune Uveitis

Ace Therapeutics' expert team induces EAU in B10.RIII mice or Lewis rats by immunization with human interphotoreceptor retinol-binding protein (IRBP) peptide or retinal soluble antigen (S-Ag) inflammation. These models develop a transient CD4+ T cell-mediated ocular immune response, mimicking human autoimmune uveitis. Rat or mouse models can be used to study panuveitis or posterior uveitis.

Available Support Services

Ace Therapeutics provides the following modeling standard evaluation and ophthalmic product efficacy evaluation services:

EAU clinical score
Histopathological evaluation of EAU
Fundus photography and OCT
Determination of cytokine production
Flow cytometry analysis

Ace Therapeutics is committed to being your trusted partner in eye disease research. Our researchers are equipped to provide unrivaled custom solutions for the EAU model for your project development. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

Caspi RR. Understanding autoimmune uveitis through animal models. The Friedenwald Lecture. Invest Ophthalmol Vis Sci. 2011 Mar 30;52(3):1872-9.
Agarwal RK, Silver PB, Caspi RR. Rodent models of experimental autoimmune uveitis. Methods Mol Biol. 2012;900:443-69.
Bansal S, Barathi VA, Iwata D, et al. Experimental autoimmune uveitis and other animal models of uveitis: An update. Indian J Ophthalmol. 2015 Mar;63(3):211-8.

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