Customized Rodent Models of Glaucoma

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Selecting animal models of glaucoma that best represent human disease is key to the successful translation of preclinical research into clinical practice. Ace Therapeutics has successfully developed several rodent glaucoma models with advanced technology, including IOP-dependent and IOP-independent models. Our dedicated research team will help you investigate your drug candidates and screen the most suitable glaucoma models. Here you can get any target model you want.

Rodent Models of Glaucoma

Glaucoma and Rodent Models

Glaucoma is a group of ocular diseases characterized by progressive optic neuropathy. The death of retinal ganglion cells (RGCs) is a major factor in the pathophysiology of these diseases, related to intraocular pressure (IOP) levels. Since the pathogenesis of glaucoma is still unclear, it is necessary to establish functional, reproducible and easy-to-use animal models to study the mechanism of glaucoma and the development of new therapies. Rodents have been used extensively to represent changes in glaucoma in the presence and absence of elevated intraocular pressure (IOP) because of their distinct advantages over other animal species. The advantage of rats is based on their similarity to humans with regard to anatomical and developmental features of the anterior segment, aqueous humor circulation, and changes in the optic nerve caused by elevated intraocular pressure; the advantage of mice lies in the availability of genetic tools.

Fig. 1. Regions in the eye and brain damaged in primary open-angle glaucoma (POAG). (Pang IH, et al., 2020)

Service Overview

High-quality glaucoma animal models are established to closely mimic human RGC and optic nerve loss, which helps to elucidate disease mechanisms and evaluate new therapies. As an ocular disease model provider, Ace Therapeutics has developed a variety of rodent models of glaucoma with advanced technology in recent years. At Ace Therapeutics, we use standard glaucoma induction protocols and genetic manipulation protocols to create this condition. After the model is established, our expert team verifies the model's reliability by testing multiple indicators, including:

Intraocular pressure measurement
Fundus photography (color)
Ocular coherence tomography (OCT)
Optomotry
Pathological analyses and imaging

Explore Ace Therapeutics' Rodent Models of Glaucoma

As a pioneer company with advanced technology in the development of eye disease models. With a deep understanding of glaucoma pathogenesis, Ace Therapeutics provides global customers with a variety of representative glaucoma models. These models include genetic glaucoma models and induced glaucoma models.

Genetic Glaucoma Model

Ocular hypertension glaucoma models (DBA/2J mice)
Normotensive glaucoma model (GLAST-deficient mice)

Induced Glaucoma Model

Laser-induced ocular hypertension model
Hypertonic saline episcleral intravenous injection model
Bead injection model
Episcleral vein cautery model
Acute elevated intraocular pressure model

What appeals to our clients is that our glaucoma models are not limited to rodents. To fully characterize your drug candidate, our talented scientists have also developed glaucoma models for other species, including zebrafish, rabbits, dogs, etc. Consult our scientists to choose the most appropriate glaucoma model for your drug candidate.

Thanks to the in-depth understanding of the pathogenesis of glaucoma, Ace Therapeutics has developed a variety of genetic glaucoma models and induced glaucoma models for global customers. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

Pang IH, Clark AF. Inducible rodent models of glaucoma. Prog Retin Eye Res. 2020 Mar;75:100799.
Johnson TV, Tomarev SI. Rodent models of glaucoma. Brain Res Bull. 2010 Feb 15;81(2-3):349-58.

For Research Use Only.

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