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Customized Rodent Models of Diabetic Retinopathy

Rodents have been most extensively studied in the field of diabetic retinopathy due to their short generation time and genetic hyperglycemia and/or obesity affecting some strains. As one of the world's leading developers and suppliers of eye disease models, Ace Therapeutics has successfully developed a series of rodent diabetic retinopathy models to serve global customers. We are happy to provide a high-quality service for your research.

Rodent Models of Diabetic Retinopathy

Diabetic Retinopathy (DR) & Rodent Models

Diabetic retinopathy (DR), an eye disease caused by diabetes that can lead to vision loss and blindness in diabetics, affects blood vessels in the retina, the light-sensitive layer of tissue at the back of the eye. DR pathology culminates in diabetes-related macular edema (DME) and proliferative diabetic retinopathy (PDR). DR in rodents is most extensively studied today because of its short generation time and hereditary hyperglycemia and/or obesity affecting certain strains. In particular, mice have proven useful for studying DR and evaluating new therapies. This is because they are easy to genetically manipulate and are suitable for replicating the early stages of non-proliferative retinopathy.

Fig. 1. Features of DR. (Quiroz J, et al., 2021)

Service Overview

In order to simulate human DR conditions in rodents, Ace Therapeutics uses a variety of methods to induce DR eye disease models at different stages, including drug induction, diet induction, genetic manipulation, and environmental exposure. The diabetic retinopathy model we provide covers the entire process of the disease, from no obvious retinal vascular changes in the early stage to obvious vascular leakage in the later stages of the lesion.

Explore Ace Therapeutics' Rodent Models of Diabetic Retinopathy

Over the past few years, talented scientists at Ace Therapeutics have gained a deeper understanding of the mechanisms underlying diabetic retinopathy. They have developed the following rodent models of diabetic retinopathy, including but not limited to.

Streptozotocin (STZ)-Induced Rodent Models of Diabetic Retinopathy

This model is used for early diabetic retinopathy studies with no apparent vascular changes. Our expert team induced insulin-dependent diabetes mellitus (T1D) in rats or mice at doses of 40-60 mg/kg STZ administered intraperitoneally or intravenously.

Diet-Induced Rodent Models of Diabetic Retinopathy

This model is for your study of retinal complications caused by elevated blood glucose levels produced by diet alone. Experimental galactosemia performed by our expert team by feeding 30-50% galactose induces diabetic retinopathy. It allows retinal characteristics analysis in animals older than 1 year.

Genetic manipulation-Induced Rodent Models of Diabetic Retinopathy

Our genetic rodent models of diabetic retinopathy include:

Rodent	Species	Basis for your selection
Rats	Biobreeding (BB) rat model	Studying responses to environmental factors and genetic aspects of diabetes.
	Zucker diabetic fat (ZDF) rats	Studying obesity-associated diabetes, primarily vascular changes in DR
	Goto-kakizaki (GK) rats	Studying long-term retinal circulation.
	Wistar bonn/Kobori (WBN/Kob) rats	Studying neuronal degeneration in DR, mainly photoreceptor apoptosis and diabetic choroidal vasculopathy.
	Otsuka long-evans tokushima fatty (OLETF) rat	Studying obesity-related diabetes
Mouse	Non-obese diabetic (NOD) mice	Investigating immune response-based therapies for diabetes.
	Akita mouse	Studying vascular changes, neuropathy, and skeletal complications of diabetes.
	Japanese kuo kondo (KK) mouse	Studying obesity-related diabetes.
	Db/db (Lepr db) mice	Studying diabetes-induced neurodegeneration

Environmental Exposure-Induced Rodent Models of Diabetic Retinopathy

Oxygen-Induced Retinopathy (OIR) Model
Mouse OIR Model

Fortunately, Ace Therapeutics' diabetic retinopathy models are not limited to the above-mentioned rodent models. We also provide zebrafish, dogs, rabbits, and other diabetic retinopathy models for global customers. Please consult our scientists today if you need further information or a customized model.

Ace Therapeutics offers the most comprehensive rodent models of diabetic retinopathy to support researchers' project development. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

Olivares AM, Althoff K, Chen GF, et al. Animal Models of Diabetic Retinopathy. Curr Diab Rep. 2017 Aug 24;17(10):93.
Quiroz J, Yazdanyar A. Animal models of diabetic retinopathy. Ann Transl Med. 2021 Aug;9(15):1272.

For Research Use Only.

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