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- BBB DamageCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
Primary Cells
Primary cells are primary cultured cells isolated from fresh living tissues, such as organs, embryos, and peripheral blood, which can maintain the basic characteristics of the original cells. With the exception of stem and progenitor cells, most primary cells are terminally differentiated cells with highly specific types and high levels of functionality. As an in vitro experimental model, primary cells have been widely used in basic research on molecules, cell biology, and biomedicine.
Primary Cells for BBB Modeling
In the context of blood-brain barrier (BBB) research, primary cells have been successfully used to model the structure and function of the BBB. The BBB is a special structure located within the walls of cerebral blood vessels that can prevent substances in the blood from entering the brain tissue to a certain extent. It is mainly composed of tightly connected cerebral vascular endothelial cells and surrounding glial cells. The physiological and pathological processes of the BBB can be better simulated and studied by using BBB models established with primary cells, , further promoting the research and treatment of blood-brain barrier-related diseases. Currently, researchers have used different types of primary cells, including endothelial cells, astrocytes and pericytes, to successfully construct blood-brain barrier models in vitro to study the BBB permeability and toxicity of drug, as well as the impact of diseases on the BBB.
Ace Therapeutics provides a variety of primary cells from humans and animals that can be used individually or in combination to create in vitro models of the BBB that mimic its physiological properties and functions. Our primary cells for BBB modeling are taken from fresh brain tissue and separated and cultured according to standardized procedures to ensure stable cell quality between different batches.
Additionally, we offer a variety of supplement media designed to balance and replenish specific cell types thus maximizing their life expectancy.
Cat.# Name Description Price BBM-C-122 Human Brain Microvascular Endothelial Cells Human Brain Microvascular Endothelial Cells (HBMECs), derived from the human brain, are a specific type of brain endothelial cells that play a crucial role in forming the blood-brain barrier (BBB). They prevent the entry of soluble and cellular substances from the blood into the brain and protect it against toxins and immune cells. These brain microvascular endothelial cells have the ability to display cell adhesion molecules on their surface, which control the migration of leukocytes into the brain. Nevertheless, when there are host-pathogen interactions outside the cells, it can activate calcium signaling within the endothelial cells, leading to the penetration of pathogens through the BBB. Human Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from normal human brain cortical tissue. Each vial contains at least 5×10^5 cells per ml and is delivered frozen.inquiry BBM-C-123 Human Brain Microvascular Pericytes Human brain microvascular pericytes (HBMVPCs) perform numerous tasks which include playing a vital part in constructing and maintaining the blood-brain barrier, controlling angiogenesis, ensuring endothelial cell survival, and engulfing cellular waste. Human Brain Microvascular Pericytes from Ace Therapeutics are isolated from normal human brain cortical tissue. Each vial contains at least 5×10^5 cells per ml and is delivered frozen.inquiry BBM-C-124 Human Astrocytes Human Astrocytes from Ace Therapeutics are isolated from the human cerebral cortex, cryopreserved at passage one. Each vial contains at least 5×10^5 cells per ml and is delivered frozen.inquiry BBM-C-125 CD1 Mouse Brain Microvascular Endothelial Cells CD1 Mouse Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from brain tissue of pathogen-free laboratory mice. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-126 C57BL/6 Mouse Embryonic Brain Endothelial Cells C57BL/6 Mouse Embryonic Brain Endothelial Cells from Ace Therapeutics are isolated from brain tissue of pathogen-free laboratory mice at embryonic day 14.5-19. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-127 C57BL/6 Mouse Brain Microvascular Endothelial Cells C57BL/6 mouse brain endothelial cells (MBREC) from Ace Therapeutics are isolated from the brain tissue of pathogen-free laboratory mice. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-128 BALB/c Mouse Brain Microvascular Endothelial Cells BALB/c Mouse Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from the brain tissue of pathogen-free laboratory mice. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-129 Rat Brain Microvascular Endothelial Cells Rat Primary Brain Microvascular Endothelial Cells (RPBECs) from Ace Therapeutics are isolated from the brain tissue of 1-day-old neonatal Sprague-Dawley rats. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-130 Bovine Brain Microvascular Endothelial Cells Bovine Brain Microvascular Endothelial Cells (BBMVEC) from Ace Therapeutics are isolated from microvessels of the bovine brain. The cells are cryopreserved at the second passage.inquiry BBM-C-131 Cynomolgus Monkey Brain Microvascular Endothelial Cells Cynomolgus Monkey Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from Cynomolgus monkey brain tissue. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-132 Porcine Brain Microvascular Endothelial Cells Porcine Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from healthy porcine brain tissue. Porcine Brain Microvascular Endothelial Cells are grown in T25 tissue culture flasks pre-coated with a gelatin-based solution for 0.5 hours and incubated in Ace Therapeutics’s Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-133 Canine Brain Microvascular Endothelial Cells Canine Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from the brain of a pathogen-free laboratory beagle dog. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.inquiry BBM-C-134 Rabbit Brain Microvascular Endothelial Cells Rabbit Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from the brain tissue of a pathogen-free New Zealand White Rabbit. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-135 Mouse Brain Vascular Pericytes (MBVP) Mouse Brain Vascular Pericytes (MBVP) from Ace Therapeutics are isolated from adult mouse brains and cryopreserved at P2. MBVP express Neural/glial antigen 2 (NG2) and α-smooth muscle actin. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry BBM-C-136 Rat Brain Vascular Pericytes (RBVP) Rat Brain Vascular Pericytes (RBVP) from Ace Therapeutics are isolated from adult rat brains and cryopreserved at P2. MBVP expresses Neural/glial antigen 2 (NG2) and α-smooth muscle actin. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.inquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.
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