Cat.#: BBM-C-130
| Source | Brain |
| Disease | Normal |
| Species | Bovine |
| Cell Type | Endothelial |
| Description | Bovine Brain Microvascular Endothelial Cells (BBMVEC) from Ace Therapeutics are isolated from microvessels of the bovine brain. The cells are cryopreserved at the second passage. |
| Applications | The Bovine Brain Microvascular Endothelial Cells (BBMVEC), a model for studying the blood-brain barrier (BBB), allows researchers to investigate the transport of drugs across the blood-brain barrier, examine brain endothelial cell tight junctions, and explore the basic biology of brain microvascular endothelial cells more effectively. The endothelial cells in this system exhibit tight junctions (positive for proteins ZO-1 and Claudin-1) and have transport characteristics similar to those found in the blood-brain barrier (such as P-glycoprotein function). Therefore, it can be used in initial ADME-Tox screening assays to determine if test compounds are likely to penetrate the blood-brain barrier. |
| Quality Control | Bovine Brain Microvascular Endothelial Cells (BBMVEC) test negative for bacteria, yeast, fungi, and mycoplasma. |
| Shipping and Storage | Ace Therapeutics ships frozen cells using dry ice. Upon receiving the frozen cells, immediately move them into liquid nitrogen (-180 °C) for storage. Note: Never can cells be kept at -20 °C, and repeated freezing and thawing of cells is not recommended. |
| Cat.# | Name | Description | Price |
|---|---|---|---|
| BBM-C-150 | Rabbit Astrocytes |
Rabbit Astrocytes from Ace Therapeutics are isolated from rabbit brains and are cryopreserved at passage one. Rabbit Astrocytes are characterized by immunofluorescence with antibody specific to GFAP. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-142 | Mouse Astrocytes-brain stem from CD1 |
Mouse Astrocytes-brain stem from CD1 (MA-bs) are isolated from embryonic day 15 mouse brain stem. MA-bs are cryopreserved as primary cultures and delivered frozen.
|
inquiry |
| BBM-C-129 | Rat Brain Microvascular Endothelial Cells |
Rat Primary Brain Microvascular Endothelial Cells (RPBECs) from Ace Therapeutics are isolated from the brain tissue of 1-day-old neonatal Sprague-Dawley rats. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-137 | Rabbit Cerebrovascular Pericytes Cells |
Rabbit Cerebrovascular Pericytes from Ace Therapeutics are isolated from the brain tissue of a pathogen-free New Zealand White Rabbit. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-149 | Bovine Astrocytes |
Bovine astrocytes from Ace Therapeutics are isolated from the bovine brain and are cryopreserved at passage one. Bovine astrocytes are characterized by immunofluorescence with antibody specific to GFAP. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-122 | Human Brain Microvascular Endothelial Cells |
Human Brain Microvascular Endothelial Cells (HBMECs), derived from the human brain, are a specific type of brain endothelial cells that play a crucial role in forming the blood-brain barrier (BBB). They prevent the entry of soluble and cellular substances from the blood into the brain and protect it against toxins and immune cells. These brain microvascular endothelial cells have the ability to display cell adhesion molecules on their surface, which control the migration of leukocytes into the brain. Nevertheless, when there are host-pathogen interactions outside the cells, it can activate calcium signaling within the endothelial cells, leading to the penetration of pathogens through the BBB.
Human Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from normal human brain cortical tissue. Each vial contains at least 5×10^5 cells per ml and is delivered frozen.
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inquiry |
| BBM-C-135 | Mouse Brain Vascular Pericytes (MBVP) |
Mouse Brain Vascular Pericytes (MBVP) from Ace Therapeutics are isolated from adult mouse brains and cryopreserved at P2. MBVP express Neural/glial antigen 2 (NG2) and α-smooth muscle actin. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
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inquiry |
| BBM-C-144 | Rat Astrocytes |
Rat Astrocytes (RA) from Ace Therapeutics are isolated from postnatal day 2 rat brains and are cryopreserved as primary cultures. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
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inquiry |
| BBM-C-148 | Rat Astrocytes-adult |
Rat Astrocytes-adult (RA-a) from Ace Therapeutics are isolated from adult CD® IGS rat brains and are cryopreserved after purification. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-125 | CD1 Mouse Brain Microvascular Endothelial Cells |
CD1 Mouse Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from brain tissue of pathogen-free laboratory mice. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
|
inquiry |
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.