Cat.#: BBM-C-130
| Source | Brain |
| Disease | Normal |
| Species | Bovine |
| Cell Type | Endothelial |
| Description | Bovine Brain Microvascular Endothelial Cells (BBMVEC) from Ace Therapeutics are isolated from microvessels of the bovine brain. The cells are cryopreserved at the second passage. |
| Applications | The Bovine Brain Microvascular Endothelial Cells (BBMVEC), a model for studying the blood-brain barrier (BBB), allows researchers to investigate the transport of drugs across the blood-brain barrier, examine brain endothelial cell tight junctions, and explore the basic biology of brain microvascular endothelial cells more effectively. The endothelial cells in this system exhibit tight junctions (positive for proteins ZO-1 and Claudin-1) and have transport characteristics similar to those found in the blood-brain barrier (such as P-glycoprotein function). Therefore, it can be used in initial ADME-Tox screening assays to determine if test compounds are likely to penetrate the blood-brain barrier. |
| Quality Control | Bovine Brain Microvascular Endothelial Cells (BBMVEC) test negative for bacteria, yeast, fungi, and mycoplasma. |
| Shipping and Storage | Ace Therapeutics ships frozen cells using dry ice. Upon receiving the frozen cells, immediately move them into liquid nitrogen (-180 °C) for storage. Note: Never can cells be kept at -20 °C, and repeated freezing and thawing of cells is not recommended. |
| Cat.# | Name | Description | Price |
|---|---|---|---|
| BBM-C-126 | C57BL/6 Mouse Embryonic Brain Endothelial Cells |
C57BL/6 Mouse Embryonic Brain Endothelial Cells from Ace Therapeutics are isolated from brain tissue of pathogen-free laboratory mice at embryonic day 14.5-19. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
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inquiry |
| BBM-C-125 | CD1 Mouse Brain Microvascular Endothelial Cells |
CD1 Mouse Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from brain tissue of pathogen-free laboratory mice. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-137 | Rabbit Cerebrovascular Pericytes Cells |
Rabbit Cerebrovascular Pericytes from Ace Therapeutics are isolated from the brain tissue of a pathogen-free New Zealand White Rabbit. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
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inquiry |
| BBM-C-132 | Porcine Brain Microvascular Endothelial Cells |
Porcine Brain Microvascular Endothelial Cells from Ace Therapeutics are isolated from healthy porcine brain tissue. Porcine Brain Microvascular Endothelial Cells are grown in T25 tissue culture flasks pre-coated with a gelatin-based solution for 0.5 hours and incubated in Ace Therapeutics’s Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
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inquiry |
| BBM-C-148 | Rat Astrocytes-adult |
Rat Astrocytes-adult (RA-a) from Ace Therapeutics are isolated from adult CD® IGS rat brains and are cryopreserved after purification. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
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inquiry |
| BBM-C-142 | Mouse Astrocytes-brain stem from CD1 |
Mouse Astrocytes-brain stem from CD1 (MA-bs) are isolated from embryonic day 15 mouse brain stem. MA-bs are cryopreserved as primary cultures and delivered frozen.
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inquiry |
| BBM-C-138 | C57BL/6 Mouse Astrocytes |
C57BL/6 Mouse Astrocytes from Ace Therapeutics are isolated from brain tissues of pathogen-free laboratory mice. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
|
inquiry |
| BBM-C-150 | Rabbit Astrocytes |
Rabbit Astrocytes from Ace Therapeutics are isolated from rabbit brains and are cryopreserved at passage one. Rabbit Astrocytes are characterized by immunofluorescence with antibody specific to GFAP. Each vial contains at least 0.5×10^6 cells per ml and is delivered frozen.
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inquiry |
| BBM-C-145 | Wistar Rat Astrocytes |
Characterization: 1. Cell Activity;
– Recovery Viability ≥ 80%.
2. Cell Purity;
– GFAP-positive cells ≥ 70%.
– β-tubulin III- or doublecortin- (Dcx-) positive cells ≤ 10%.
– GalC-positive cells ≤ 10%.
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inquiry |
| BBM-C-139 | CD1 Mouse Astrocytes |
CD1 Mouse Astrocytes from Ace Therapeutics are isolated from postnatal day 2 mouse brains. MA is characterized by immunofluorescence with antibodies specific to GFAP. Each vial contains at least 1×10^6 cells per ml and is delivered frozen.
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inquiry |
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.