Customized In Vivo Ocular Models ace

Customized In Vivo Ocular Models

Animal models of ocular diseases are powerful tools for evaluating ophthalmic drugs' efficacy. As a contract research organization for preclinical ophthalmology research, Ace Therapeutics provides global customers with eye disease animal models covering multiple species, for example, rodent eye disease models, zebrafish eye disease models, rabbit eye disease models, etc., to achieve targeted and significant preclinical drug discovery and development programs. With the wealth of information we have on models for each ocular disease, our talented scientists can also help you choose the most appropriate model and assay to meet the specific needs of a particular compound or discovery program.

Animal Models of Ocular Diseases

Why Do You Need Animal Models of Ocular Disease?

Due to the complexity of the pathogenesis of ocular diseases, there are limitations in time and space when using humans as research objects to explore the pathogenesis of diseases. Many experiments are also limited in ethics and methods. With the help of indirect research on animal models of ocular diseases, it is more convenient and accurate to observe the experimental results of the models and conduct comparative studies with human diseases, which helps to more effectively understand the occurrence and development of eye diseases and find preventive measures. In addition, at the development stage of ophthalmic drugs, observing the effects of drugs on animal models of eye diseases can help scientists predict the effects of drugs on humans. Therefore, suitable animal models of eye diseases, such as monkeys, mice, rats, and zebrafish, are very valuable for studying the molecular mechanisms of eye diseases and testing new therapeutic interventions.

Fig. 1. Cross-sectional view of the human and zebrafish retina indicating the similar structural features of the retinal layers. (Hong Y, et al., 2021)

Service Overview

Selecting the correct preclinical ocular disease model is a critical factor in the success of your project. As a full-service ophthalmology research preclinical CRO, Ace Therapeutics offers hundreds of validated ocular disease models. Our experienced scientists understand all critical steps in innovative ocular disease model development. Throughout the design and development process of ocular disease models, our core standard is the strict collection and interpretation of considerable data. You will benefit from our high-standard design concepts and services to promote your project's innovation.

In addition, we also provide a series of strict supporting services, such as eye examination services (pre-screening and drug efficacy characterization), to ensure that the probability of success is greatly improved during the entire project promotion period, and unnecessary negative effects.

Explore Ace Therapeutics' Animal Models of Ocular Disease

The establishment of a stable and reliable ocular disease model plays a decisive role in the study of the pathogenesis of ophthalmic diseases, the study of drug targets, and the evaluation of pharmacodynamics. Ace Therapeutics' ophthalmology research team has extensive experience in disease model generation for ocular diseases. Our expert team has developed various ocular diseases with the help of gene knock-in, knock-out and physico-chemical stimulation. This facilitates the development of pharmacodynamic experiments and drug safety assessment in the most efficient and cost-effective manner possible. Our ocular disease models portfolio covers the following species, including but not limited to：

Advantages of Ace Therapeutics' Ocular Diseases Models

Complementary multispecies ocular disease models.
An experienced ocular gene manipulation team can design eye genetic models that accurately characterize genes' biological functions.
Support the development of a full range of eye disease models.
A series of supporting inspection services, including ophthalmological pre-screening and drug efficacy evaluation.
Customized model development services according to customer project needs.

Benefit from extensive experience in the development of ocular disease models. Ace Therapeutics is pleased to share our best-in-class technology and advanced ocular disease models with global customers. In addition, we provide customized eye disease model screening and safety assessment services for ophthalmology research of global customers. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

Chang B, Hawes NL, Hurd RE, et al. Mouse models of ocular diseases. Vis Neurosci. 2005 Sep-Oct;22(5):587-93.
Hong Y, Luo Y. Zebrafish Model in Ophthalmology to Study Disease Mechanism and Drug Discovery. Pharmaceuticals (Basel). 2021 Jul 25;14(8):716.

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