Advantages of Rabbits for Ocular Disease Research

Irreversible visual impairment and blindness are one of the major factors affecting the quality of life of an increasing number of people worldwide. Despite significant advances in modern ophthalmology, eye diseases remain challenging. The development of novel drugs and drug delivery mechanisms as well as advanced ophthalmic technologies requires experimental models, including animals, capable of developing ocular diseases with similar etiology and pathology, suitable for future trials of new therapeutic approaches. Rabbits are widely used to study ocular physiology and pathology due to their relatively large eye size and similar structure to the human eye. Various rabbit eye disease models have been established, such as dry eye, age-related macular degeneration and glaucoma, retinal detachment, lens regeneration, wound healing, and other ocular diseases. In addition, rabbit models are commonly used to study surgical interventions such as cataract removal, laser refractive surgery, intraocular lens insertion, corneal transplantation, glaucoma shunt implantation, and intravitreal drug delivery. Therefore, compared to rodents, rabbit models are more suitable for preclinical drug efficacy and safety studies, testing novel drug delivery methods.

Fig. 1. Classification and timeline of generation of various rabbit models of meibomian gland dysfunction. (Prasad D, et al., 2023)

Service Overview

As one of the world's leading developers and suppliers of eye disease models, over the past few years, Ace Therapeutics has been committed to developing innovative multi-species eye disease models to shorten project development and product launch time for customers. One of them is the rabbit ocular disease model because the rabbit model is more suitable for preclinical ophthalmic pharmacology research to evaluate the efficacy and safety of novel drugs.

It is worth mentioning that Ace Therapeutics has explored and developed a variety of rabbit ocular disease models and allowed the testing of novel drug delivery methods.

Explore Ace Therapeutics' Rabbit Ocular Disease Models

Ace Therapeutics has established an experienced matrix of preclinical ophthalmology studies to assist our clients in model screening and efficacy evaluation, which is done in the most efficient and cost-effective manner. Our talented researchers use surgery and physicochemical stimuli to model different eye diseases. Importantly, our rabbit models have been validated through extensive experiments to describe the biological mechanisms involved in the development of ocular diseases. Please click on the links below for details on the different rabbit ocular models.

• Rabbit Models of DL-AAA-Induced Retinal Neovascularization
• Rabbit Models of Dry Eye Disease
• Rabbit Models of Corneal Neovascularization
• Rabbit Models of Normotensive & Hypertensive Intraocular Pressure
• Rabbit Models of Uveiti
• Rabbit ModelS of Proliferative Vitreoretinopathy
• Rabbit Models of Ocular Pain
• Rabbit Models of Corneal Endothelial Injury
• Rabbit Models of Retinoblastoma
• Rabbit Models of Uveal Melanoma

Ocular Diagnostic Tools

• Fluorescein angiography
• Scheimpfilug analysis
• Histopathology
• Comeal confiocal microscopy
• Fundoscopic imaging
• Optical coherence tomography
• Slit lamp microbiography
• Indirect ophthalmoscopy
• Tonometry
• Electroretinography

Advantages of Ace Therapeutics' Rabbit Ocular Disease Models

• The rabbit ocular disease model covers a wide range, including glaucoma, dry eye disease, ocular pain, ocular cancer, etc.
• More suitable for testing the delivery methods of the ocular drugs.
• Low incidence of adverse reactions during the study.
• A series of supporting inspection services: ophthalmic pre-screening, and drug efficacy evaluation.
• Customize model development services according to customer project needs.

Thanks to our in-depth understanding of rabbit and eye diseases, Ace Therapeutics has established the world's most comprehensive laboratory for rabbit eye disease models. Our scientists can select and customize the best model according to your project. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Prasad D, Salman M, Reddy AA, et al. A review of rabbit models of meibomian gland dysfunction and scope for translational research. Indian J Ophthalmol. 2023, 71(4):1227-1236.
2. Zernii EY, Baksheeva VE, Iomdina EN, et al. Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches. CNS Neurol Disord Drug Targets. 2016, 15(3):267-91.

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• Customized Non-Human Primate (NHP) Models of Ocular Diseases

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