Advantages of Non-Human Primate (NHP) for Ocular Disease Research

According to incomplete statistics, about 900 million people suffer from visual impairment around the world. Glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), high myopia, and cataracts are the most common ocular diseases that cause irreversible blindness worldwide. To elucidate the pathogenesis of these ocular diseases, it is essential to develop animal models that mimic the biological mechanisms of human disease ocular diseases to study the disease process. In various animal models, non-human primate (NHP) is considered an attractive model, and its advantages for vision research are as follows: 1) Unlike small animals such as mice, NHP has eye structures more similar to humans, such as the macula structure and vitreous volume. 2) Rhesus monkeys have more than 90% DNA sequences and highly conserved protein sequences with humans and have great similarities in anatomy, physiology, and genetics. 3) Using invasive methods and novel treatments in NHP research may complement studies in human volunteers and patients. 4) Availability and similarity of instruments for ocular phenotyping. These advantages determine that NHP can provide precise and conclusive data for preclinical research on human visual biology and ocular diseases, thereby ensuring a higher success rate of clinical research.

Fig. 1. Anatomy of the rodent and primate eye. (Picaud S, et al., 2019)

Explore Ace Therapeutics' Non-Human Primate (NHP) Ocular Disease Models

Ace Therapeutics, one of the world's leading leaders in ocular disease modeling, is one of the professional organizations in non-human primate (NHP) models. We want to help you accelerate the journey of your pipeline discovery with our NHP models. Here, we look forward to working with you to explore promising therapies for improving the life quality of ocular patients.

Our NHP models are crucial key tools in your preclinical research, dramatically improving your understanding of many eye diseases and giving you greater insight into the appropriate ways to develop vision restoration. We are proud that our NHP models have been extensively experimentally validated to characterize and mimic the physiopathological mechanisms underlying human ocular disease development.

Additionally, our NHP research center will provide you with comprehensive ocular toxicology studies. In recent years, our talented scientists have helped our partners conduct multiple toxicology and safety assessment studies in NHP models with promising results.

Please click on the link below to learn about the NHP ophthalmic models used in pivotal preclinical studies.

• Non-Human Primate (NHP) Models of Laser-Induced Chronic Ocular Hypertension
• Non-Human Primate (NHP) Models of Retinal Ischemia-Reperfusion Injury
• Non-Human Primate (NHP) Models of Dry Eye Disease
• Non-Human Primate (NHP) Models of Blue Light-Induced Retinal Degeneration
• Non-Human Primate (NHP) Models of Laser-Induced Choroidal Neovascularization (CNV)
• Non-Human Primate (NHP) Models of Uveitis
• Non-Human Primate (NHP) Models of Inherited Retinal Diseases

Note*: Ace Therapeutics also offers custom NHP ocular disease models!

Ocular Diagnostic Tools

• Fluorescein angiography
• Scheimpfilug analysis
• Histopathology
• Comeal confiocal microscopy
• Fundoscopic imaging
• Optical coherence tomography
• Slit lamp microbiography
• Indirect ophthalmoscopy
• Tonometry
• Electroretinography

Advantages of Ace Therapeutics' Minipig Ocular Disease Models

• Multiple validated disease animal models for supporting research in glaucoma, retinal degeneration, dry eye disease, etc.
• Supporting gene therapy, stem cell transplantation research, intraocular implant development, etc.
• Low incidence of adverse reactions during the study.
• A series of supporting inspection services: ophthalmic pre-screening, and drug efficacy evaluation.
• Tailored solutions according to customer project needs.

Thanks to our in-depth understanding of NHP, Ace Therapeutics has established a comprehensive experimental platform for NHP ocular disease models. Our scientists can select and customize the most appropriate model according to your project. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Picaud S, Dalkara D, Marazova K, et al. The primate model for understanding and restoring vision. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26280-26287.
2. Mustari MJ. Nonhuman Primate Studies to Advance Vision Science and Prevent Blindness. ILAR J. 2017, 58(2):216-225.

• Customized Rodent Models of Ocular Diseases
• Customized Zebrafish Models of Ocular Diseases
• Customized Rabbit Models of Ocular Diseases
• Customized Minipig Models of Ocular Diseases
• Customized Canine Models of Ocular Diseases
• Customized Chicken Models of Ocular Diseases

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