In Vivo Models of Diabetes Mellitus
Ace Therapeutics' comprehensive portfolio of diabetic animal models and custom modeling services enables us to help our clients research, discover and develop new therapies.
Introduction to In Vivo Models of Diabetes Mellitus
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both. To better understand the pathophysiology of diabetes and develop effective treatments, in vivo models of diabetes are indispensable. These models simulate the human disease condition, allowing researchers to study disease mechanisms, evaluate potential therapeutic agents, and investigate complications associated with diabetes.
Fig. 1. Animal models for diabetes. (King A, et al., 2016)
Our Diabetic Animal Model Development Services
At Ace Therapeutics, we specialize in customizing a variety of diabetes animal models tailored to meet specific research needs. Whether the objective is to develop a specific approach to animal modelling for diabetes or to study a particular type of diabetes, we can provide a comprehensive animal modelling solution.
Our Methods for Diabetic Animal Model Development
Spontaneous Models of Diabetes Mellitus
Diet-Induced Models of Diabetes
Surgically Induced Models of Diabetes
Chemically Induced Models of Diabetes
Genetically Engineered Models of Diabetes
Spontaneous Models of Diabetes Mellitus
We offer custom development services for spontaneous diabetes models that naturally develop the disease without external interventions, closely mimicking human diabetes. For example, we can develop the NOD mouse model for Type 1 diabetes and the ZDF rat model for Type 2 diabetes.
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Diet-Induced Models of Diabetes
Our team provides custom development of diet-induced diabetes models by feeding animals a high-fat or high-sugar diet, leading to obesity and insulin resistance. These models are highly effective for replicating Type 2 diabetes, making them invaluable for studying metabolic syndrome and diet-related diabetes.
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Surgically Induced Models of Diabetes
We provide custom solution of diabetic models through surgical procedures, such as partial pancreatectomy, to reduce insulin secretion capacity. These models are particularly useful for researching pancreatic beta-cell function and the mechanisms of diabetes development.
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Chemically Induced Models of Diabetes
We provide custom development of chemically induced models using agents like streptozotocin (STZ) or alloxan to selectively destroy pancreatic beta cells, resulting in Type 1 diabetes. These models are critical for investigating autoimmune diabetes and beta-cell regeneration.
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Genetically Engineered Models of Diabetes
Our team utilizes advanced genetic engineering techniques to develop custom transgenic and knockout models that exhibit specific genetic mutations associated with diabetes. These models provide insights into the genetic basis of diabetes and facilitate the development of gene therapies.
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Modelling Services by Type of Diabetes Mellitus
Type 1 Diabetes
We provide models that replicate the autoimmune destruction of beta cells, leading to insulin deficiency. These models are essential for studying the pathogenesis of T1DM and developing new treatments and interventions.
Type 2 Diabetes
Our models exhibit insulin resistance and beta-cell dysfunction, reflecting the complex etiology of Type 2 diabetes. These models are valuable for researching the underlying mechanisms of T2DM and for testing potential therapies aimed at improving insulin sensitivity and beta-cell function.
Gestational Diabetes
We offer models designed to study glucose intolerance that develops during pregnancy.
Diabetic Complications
- Modeling of Diabetic Complications
Our comprehensive models facilitate the investigation of various diabetic complications, including diabetic nephropathy, neuropathy, retinopathy, and cardiovascular diseases.
Diabetic Animal Model Validation Services
We provide comprehensive validation services to ensure the reliability and reproducibility of our diabetes models. Our validation services include
- Phenotypic characterization
- Histopathological analysis
- Genomic studies
- Biochemical assays
- Metabolic profiling
- Proteomic studies
Applications of Diabetic Animal Models
- Mechanistic studies of diabetes pathophysiology
- Investigation of diabetic complications
- Drug discovery
- Evaluation of novel therapeutic targets
- Preclinical testing of new drugs
- Nutritional and lifestyle intervention studies
For additional information about how our services can be customized to meet your exact needs, please contact us. Let Ace Therapeutics be your partner in advancing diabetes research and developing innovative therapies for diabetes mellitus.
Reference
- King A, Bowe J. (2016). Animal models for diabetes: Understanding the pathogenesis and finding new treatments. Biochem Pharmacol. 99:1-10.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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