Animal models fed a high-fat/high-sugar diet offer a valuable opportunity to evaluate the efficacy of compounds in treating obesity-induced diabetes (diabesity) through various approaches. Ace Therapeutics helps researchers investigate certain aspects of diabetes-related metabolic syndrome endpoints by using specific diets, appropriate positive controls, and a robust set of analytical endpoints.
Diabetes is a pressing global health concern linked to factors like diet, genetics, and physical inactivity. Dietary choices play a crucial role in the development of diabetes, contributing significantly to its rise in modern society. While valuable insights have been gained from studies using inbred strains, transgenic and knockout mice, the polygenic nature of diabetes necessitates the development of models that mimic diet-induced obesity and diabetes. These models are crucial for investigating diseases and testing the efficacy of therapeutic compounds in preventing or reversing obesity, insulin resistance, and diabetes.
Fig. 1. Long-term consequences of obesity and diabetes mellitus. (Selman A, et al., 2022)
We specialize in developing various diet-induced diabetes models to help clients evaluate the efficacy of drug candidates and study the pathological mechanisms associated with obesity and diabetes.
| Species | Advantages |
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| Hamster |
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| Dog |
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At Ace Therapeutics, we provide well-characterized diet-induced diabetes models that are appropriate for studying pre-diabetes and diabetes-related metabolic syndrome.
To develop effective prevention and treatment strategies, it is crucial to develop animal models that resemble human diabetes. We provide customers with high-fat diet-induced diabetes models that would effectively replicate type 2 diabetes.
The main factors considered by our researchers when designing a high-fat diet-induced diabetes model include:
| Diet Formulation | Purified Ingredient Diet |
| Fat Content | 32% to 60% |
| Types of Fats | lard, beef tallow, coconut oil, milk fat, fish oils |
| Commonly Used Species | C57BL/6J mice, AKR/J mice, Sprague-Dawley rats, Wistar rats, F344x Brown Norway rats |
Our team offers high sugar diet-induced diabetes models that provide valuable tools to recapitulate the metabolic abnormalities associated with type 2 diabetes. These models are helpful to study the influence of a high-sugar diet on the development of diabetes.
| Diet Formulation | Purified Ingredient match |
| Types of Sugars | High fructose, High sucrose |
| Commonly Used Strains | Sprague-Dawley rats, Wistar rats, Hamsters, C57BL/6 mice, LDLR-/- mice |
Ace Therapeutics provides various assessment options for testing the effectiveness of potential therapies targeting diabetes depending on your study objectives. Our assessments include but are not limited to:
For more information on how our services can be customized to meet your specific needs, please contact us. By collaborating with Ace Therapeutics, researchers gain access to reliable animal models and expert support, propelling diabetes research forward.
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
