Animal models fed a high-fat/high-sugar diet offer a valuable opportunity to evaluate the efficacy of compounds in treating obesity-induced diabetes (diabesity) through various approaches. Ace Therapeutics helps researchers investigate certain aspects of diabetes-related metabolic syndrome endpoints by using specific diets, appropriate positive controls, and a robust set of analytical endpoints.

Overview of Diet-Induced Diabetes Models

Diabetes is a pressing global health concern linked to factors like diet, genetics, and physical inactivity. Dietary choices play a crucial role in the development of diabetes, contributing significantly to its rise in modern society. While valuable insights have been gained from studies using inbred strains, transgenic and knockout mice, the polygenic nature of diabetes necessitates the development of models that mimic diet-induced obesity and diabetes. These models are crucial for investigating diseases and testing the efficacy of therapeutic compounds in preventing or reversing obesity, insulin resistance, and diabetes.

Fig. 1. Long-term consequences of obesity and diabetes mellitus. (Selman A, et al., 2022)

Animal Selection for Diet-Induced Diabetes Modeling

We specialize in developing various diet-induced diabetes models to help clients evaluate the efficacy of drug candidates and study the pathological mechanisms associated with obesity and diabetes.

Our Diet-Induced Diabetes Models

At Ace Therapeutics, we provide well-characterized diet-induced diabetes models that are appropriate for studying pre-diabetes and diabetes-related metabolic syndrome.

• High-Fat Diet-Induced Diabetic Models

To develop effective prevention and treatment strategies, it is crucial to develop animal models that resemble human diabetes. We provide customers with high-fat diet-induced diabetes models that would effectively replicate type 2 diabetes.

The main factors considered by our researchers when designing a high-fat diet-induced diabetes model include:

• High-Sugar Diet-Induced Diabetic Models

Our team offers high sugar diet-induced diabetes models that provide valuable tools to recapitulate the metabolic abnormalities associated with type 2 diabetes. These models are helpful to study the influence of a high-sugar diet on the development of diabetes.

Our In Vivo Analysis Services

Ace Therapeutics provides various assessment options for testing the effectiveness of potential therapies targeting diabetes depending on your study objectives. Our assessments include but are not limited to:

• Body weight
• Body composition measurement
• Blood glucose level
• Food/water intake
• Serum insulin level
• Glucose tolerance test
• Insulin tolerance test
• Histopathological evaluation
• Oxidative stress evaluation
• Biomarker analysis

For more information on how our services can be customized to meet your specific needs, please contact us. By collaborating with Ace Therapeutics, researchers gain access to reliable animal models and expert support, propelling diabetes research forward.

Reference

1. Selman A, et al. (2022) The role of obesity and diabetes in dementia. International Journal of Molecular Sciences. 23(16): 9267.

• Spontaneous Models of Diabetes Mellitus
• Surgically Induced Diabetic Models
• Chemically Induced Diabetes Models
• Genetically Engineered Diabetes Models

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• Inhibitors & Activators