The precise mechanisms underlying gestational diabetes remain unknown. The hallmark of GDM is increased insulin resistance. Pregnancy hormones and other factors are thought to interfere with the action of insulin as it binds to the insulin receptor. Disease models can be used as suitable research tools for gestational diabetes. Ace Therapeutics can provide modeling services of GDM to accelerate customer research progress.

Introduction of GDM

Gestational diabetes (GDM) is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy. It increases the risk of pre-eclampsia, depression, and of needing a caesarean section. Several changes in glucose regulation occur during normal pregnancy to facilitate nutrient supply to the developing fetus. GDM is characterized by the inability of pancreatic β-cells to respond adequately to the increased insulin requirements of pregnancy resulting in varying degrees of hyperglycemia.

Glucose is Tightly Coupled to Insulin Secretion in Pancreatic β-Cells (Wu, J. and Yan, L. J. Diabetes, Metabolic Syndrome and Obesity. 2015)

Advances in GDM Research

The etiology of GDM is complex, with genetic and environmental factors implicated in mechanistic and epidemiological studies. Scientists have conducted analysis of GDM pathology, investigation of causative factors, study of complications, influence of relevant factors, and the relationship between T2DM and GDM. The main therapy to GDM is lifestyle management or oral hypoglycemic drugs after diagnosis.

• The Therapy of GDM
  The therapies of GDM focus on the control of maternal blood glucose. Despite lifestyle changes, oral metformin and glyburide that can improve maternal glycemia to some extent, there are still patients who have poor pregnancy outcomes. There is an urgent need for more effective therapies of GDM. Animal models can be used as suitable research tools.

GDM Related Models

The development of GDM has similarities to T2DM, including autoimmunity, single gene mutations, obesity, and other mechanisms. So obese models and genetically induced models of T2DM can be used to study gestational diabetes. For example, obese mouse models (ob/ob mouse model, db/db mouse model, DIO mice, NZO mouse, ZDF rat, et al.), genetically modified models, and some cat or other large animal models can also be used to study GDM.

Our Services

The construction of diabetes models can better simulate the development of human diabetes. Ace Therapeutics providing modeling service which can be customized by customer needs. Our services include but not limited to the followings.

Features of Our Services

Ace Therapeutics offers cost-effect and high-quality research services for our clients worldwide. In addition, we offer a variety of mouse models and cell lines for diabetes research. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us.

• GDM Pathological Research Service
• GDM Therapy Development Service
• GDM Biomarker Development Service
• GDM Diagnostic Development Services

• Mouse Models
• Assay Kits
• Antibodies
• Cell Lines & Lysates
• Proteins & Peptides
• Inhibitors & Activators