Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β-cells of the endocrine pancreas. Animal models can be used as suitable research tools for diabetes. Ace Therapeutics can provide modeling services of T1DM to accelerate customer research progress.
Type 1 diabetes mellitus (T1DM) accounts for about 10% of all diabetic patients, also known as insulin dependent diabetes mellitus or juvenile diabetes, is an autoimmune disease that occurs mostly in children and adolescents. The β-cells in patients have been damaged, clinically manifested as insulin secretion disorder, increased blood sugar and ketosis tendency.
Immunologic History of Type 1 Diabetes (Jeffrey, A. B.; et al. Nature. 2016)
The pathogenesis of diabetes is complex and multifactorial. As an important research tool, experimental models of diabetes play an important role in the study of mechanisms, drug screening, and preclinical drug testing.
| Spontaneously Models | Nonobese diabetic (NOD) mouse, BioBreeding Diabetes-Prone (BB) rat and LEW-1AR1 / -iddm rat are the most widely studied models of T1DM. |
| Chemically Induced | The chemical compounds alloxan and streptozotocin (STZ) are commonly used to induce diabetes and destroy β-cells in animal models. The chemically induced destruction of β-cells leads to decreased insulin production, hyperglycemia and weight loss in the experimental animal. |
| Genetically Induced | The most commonly used genetically induced T1DM model is the so-called AKITA mouse (originally C57BL/6NSIc mouse). The development of diabetes in AKITA mice is caused by a spontaneous point mutation in the Ins2 gene, which is responsible for the correct composition of insulin in the endoplasmic reticulum. |
| Virally Induced | Among the most commonly used are coxsackie virus, lymphocytic choriomeningitis virus, encephalomyocarditis virus. Examples of virus-induced animals include NOD mice infected with coxsackie B4 that developed T1DM within two weeks. |
Various animal models of disease are used to understand the pathogenesis and etiology of T1DM. Ace Therapeutics providing modeling service which can be customized by customer needs. Our services include but not limited to the followings.
Highly Customizable
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Ace Therapeutics offers cost-effect and high-quality research services for our clients worldwide. In addition, we offer a variety of mouse models and cell lines for diabetes research. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us.
