T1DM Modeling Service

Type 1 diabetes mellitus (T1DM) results from the autoimmune destruction of β-cells of the endocrine pancreas. Animal models can be used as suitable research tools for diabetes. Ace Therapeutics can provide modeling services of T1DM to accelerate customer research progress.

Overview of T1DM

Type 1 diabetes mellitus (T1DM) accounts for about 10% of all diabetic patients, also known as insulin dependent diabetes mellitus or juvenile diabetes, is an autoimmune disease that occurs mostly in children and adolescents. The β-cells in patients have been damaged, clinically manifested as insulin secretion disorder, increased blood sugar and ketosis tendency.

Fig 2. Immunologic History of Type 1 Diabetes Immunologic History of Type 1 Diabetes (Jeffrey, A. B.; et al. Nature. 2016)

T1DM Models

The pathogenesis of diabetes is complex and multifactorial. As an important research tool, experimental models of diabetes play an important role in the study of mechanisms, drug screening, and preclinical drug testing.

Mouse Models
The available models of T1DM can be divided into spontaneously autoimmune, chemically induced, virus induced and genetically induced.

Spontaneously Models	Nonobese diabetic (NOD) mouse, BioBreeding Diabetes-Prone (BB) rat and LEW-1AR1 / -iddm rat are the most widely studied models of T1DM.
Chemically Induced	The chemical compounds alloxan and streptozotocin (STZ) are commonly used to induce diabetes and destroy β-cells in animal models. The chemically induced destruction of β-cells leads to decreased insulin production, hyperglycemia and weight loss in the experimental animal.
Genetically Induced	The most commonly used genetically induced T1DM model is the so-called AKITA mouse (originally C57BL/6NSIc mouse). The development of diabetes in AKITA mice is caused by a spontaneous point mutation in the Ins2 gene, which is responsible for the correct composition of insulin in the endoplasmic reticulum.
Virally Induced	Among the most commonly used are coxsackie virus, lymphocytic choriomeningitis virus, encephalomyocarditis virus. Examples of virus-induced animals include NOD mice infected with coxsackie B4 that developed T1DM within two weeks.

Non-rodent Models
In addition to the extensively studied rodent models of T1DM, several large animal models have been developed. In large animal models, spontaneous diabetes is relatively rare and unpredictable in onset, and thus, induced models of T1DM are required. The most common method of inducing insulin dependence in large models is either by pancreatectomy or STZ.

Our Services

Various animal models of disease are used to understand the pathogenesis and etiology of T1DM. Ace Therapeutics providing modeling service which can be customized by customer needs. Our services include but not limited to the followings.

Fig 3. Types of Diabetes Model

Types of Diabetes Models

Culture Cell Models
Non-human Primate Models
Mouse, Rat, Rabbit, Guinea Pig Models
Other Animal Model (Zebrafish, Drosophila, C. elegans, et al.)

Fig 4. Genetically Modified Model

Genetically Modified Diabetes Models

Knock-out (Large Deletion)
Knock-in (Point Mutation, Large Insertion)

Features of Our Services

Highly Customizable

One-stop Services

High Qualitys High Quality

Professional Team

Ace Therapeutics offers cost-effect and high-quality research services for our clients worldwide. In addition, we offer a variety of mouse models and cell lines for diabetes research. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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