Surgically Induced Diabetic Models
Ace Therapeutics offers a variety of surgically induced diabetic animal models. Equipped with a comprehensive platform for physiological studies, we provide scientific services to support clients in studying the underlying mechanisms of diabetes and evaluating potential therapeutics.
Introduction to Surgically Induced Diabetic Animal Models
In 1889, Mering and Minkowski discovered that dogs could develop diabetes after having their pancreas surgically removed. This finding has been consistently replicated in experimental animals, establishing the scientific basis for developing surgical models of diabetes. Currently, various surgical induction methods have been developed to induce diabetes in animal models. With unique advantages, these models are widely used to elucidate the pathogenesis of diabetes mellitus (DM) and its complications.
| Advantages |
Disadvantages |
- Short interval
- Low mortality rate
- Rat or large animal model
- Complication modeling
|
- Confounding effects
- Technically fastidious
- Infection and care issues
- Ethical concerns related to animal suffering and wellbeing
|
Animal Selection of Surgically Induced Diabetic Models
| Animal Species |
Advantages |
| Rat/Mouse models |
- Reflects the effects of reduced β-cell mass
- High reproductive rate
- Cost-effective and easy handling
|
| Zebrafish models |
- Suitable for investigating specific genes and similarities in genetic pathways involved in glucose metabolism
- Small size, short life cycle, and large number of eggs
- Cost-effective and easy to maintain
|
| Rabbit models |
|
| Dog models |
- Simulating the natural development of T2D-like symptoms
- Large size and long lifespan
|
| Pig models |
- Pancreatectomy followed by autotransplantation of the isolated islets largely matches that seen in human diabetics
|
| Non-human primate models |
- Long lifespans
- Remarkable similarities to human physiology
- Easy to conduct blood sampling, endoscopy, and serial laparoscopic biopsies
|
Surgical T1D Animal Models
We provide surgically induced T1D animal models based on clients' drug development needs. The main surgical methods we use in animal modeling include:
- Total pancreatectomy
We perform pancreatectomy on small and large animals to establish T1D models. These models are suitable for evaluating the effects of insulin deficiency on glucose metabolism and the development of diabetes.
- Islet transplantation
We establish T1D models by implanting insulin-producing pancreatic β-cells into other organs in recipient animals. These models are suitable for studying the immune response to islet transplantation and evaluating the survival rate of transplanted islets in T1D models.
- Surgical removal of the thymus gland (thymectomy)
We provide thymectomy surgical models suitable for studying autoreactive T lymphocytes involved in the autoimmune destruction of pancreatic beta cells in T1D.
Surgical T2D Animal Models
We provide T2D animal models through surgical techniques, which have immeasurable value in elucidating many aspects of human T2D. Our key surgical methods include:
- Partial pancreatectomy
We induce diabetes in animals through partial pancreatectomy while minimizing damage to the liver and kidneys. These models are valuable for exploring the implications of pancreatic β-cell loss and evaluating the regenerative potential of β-cells or their progenitors.
- Bariatric surgery
Our researchers develop T2D animal models using bariatric surgery techniques, which include stomach size reduction or modulation of nutrient absorption. These models serve as robust tools for clients to investigate the impact of weight loss on enhancing insulin sensitivity and glucose metabolism.
- Renal denervation
We provide clients with renal denervation models by destroying nerves in the renal arteries. These models are suitable for exploring the role of the sympathetic nervous system in T2D development.
At Ace Therapeutics, we go beyond delivering customized diabetes animal models. We provide a full range of contract research services to bolster your scientific pursuits. Please contact us for tailored research solutions that meet your unique requirements!
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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