Surgically Induced Diabetic Models

Ace Therapeutics offers a variety of surgically induced diabetic animal models. Equipped with a comprehensive platform for physiological studies, we provide scientific services to support clients in studying the underlying mechanisms of diabetes and evaluating potential therapeutics.

Introduction to Surgically Induced Diabetic Animal Models

In 1889, Mering and Minkowski discovered that dogs could develop diabetes after having their pancreas surgically removed. This finding has been consistently replicated in experimental animals, establishing the scientific basis for developing surgical models of diabetes. Currently, various surgical induction methods have been developed to induce diabetes in animal models. With unique advantages, these models are widely used to elucidate the pathogenesis of diabetes mellitus (DM) and its complications.

Advantages	Disadvantages
Short interval Low mortality rate Rat or large animal model Complication modeling	Confounding effects Technically fastidious Infection and care issues Ethical concerns related to animal suffering and wellbeing

Animal Selection of Surgically Induced Diabetic Models

Animal Species	Advantages
Rat/Mouse models	Reflects the effects of reduced β-cell mass High reproductive rate Cost-effective and easy handling
Zebrafish models	Suitable for investigating specific genes and similarities in genetic pathways involved in glucose metabolism Small size, short life cycle, and large number of eggs Cost-effective and easy to maintain
Rabbit models	Easy to handle and house
Dog models	Simulating the natural development of T2D-like symptoms Large size and long lifespan
Pig models	Pancreatectomy followed by autotransplantation of the isolated islets largely matches that seen in human diabetics
Non-human primate models	Long lifespans Remarkable similarities to human physiology Easy to conduct blood sampling, endoscopy, and serial laparoscopic biopsies

Surgical T1D Animal Models

We provide surgically induced T1D animal models based on clients' drug development needs. The main surgical methods we use in animal modeling include:

Total pancreatectomy
We perform pancreatectomy on small and large animals to establish T1D models. These models are suitable for evaluating the effects of insulin deficiency on glucose metabolism and the development of diabetes.
Islet transplantation
We establish T1D models by implanting insulin-producing pancreatic β-cells into other organs in recipient animals. These models are suitable for studying the immune response to islet transplantation and evaluating the survival rate of transplanted islets in T1D models.
Surgical removal of the thymus gland (thymectomy)
We provide thymectomy surgical models suitable for studying autoreactive T lymphocytes involved in the autoimmune destruction of pancreatic beta cells in T1D.

Surgical T2D Animal Models

We provide T2D animal models through surgical techniques, which have immeasurable value in elucidating many aspects of human T2D. Our key surgical methods include:

Partial pancreatectomy
We induce diabetes in animals through partial pancreatectomy while minimizing damage to the liver and kidneys. These models are valuable for exploring the implications of pancreatic β-cell loss and evaluating the regenerative potential of β-cells or their progenitors.
Bariatric surgery
Our researchers develop T2D animal models using bariatric surgery techniques, which include stomach size reduction or modulation of nutrient absorption. These models serve as robust tools for clients to investigate the impact of weight loss on enhancing insulin sensitivity and glucose metabolism.
Renal denervation
We provide clients with renal denervation models by destroying nerves in the renal arteries. These models are suitable for exploring the role of the sympathetic nervous system in T2D development.

At Ace Therapeutics, we go beyond delivering customized diabetes animal models. We provide a full range of contract research services to bolster your scientific pursuits. Please contact us for tailored research solutions that meet your unique requirements!

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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