In Vivo Pharmacodynamic Evaluation of Cardiovascular Drugs

Inquiry

In vivo pharmacodynamic studies are a direct way to obtain pharmacodynamic parameters of cardiovascular drugs. Ace Therapeutics provides professional in vivo pharmacodynamic study services to support preclinical studies of cardiovascular drugs.

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Animal Models for Pharmacodynamic Studies of Cardiovascular Drugs

The pharmacological effects of different cardiovascular drugs are animal species-specific due to differences in drug type, pharmacodynamic mechanism and drug target. Therefore, the selection of appropriate animal models is a key issue in vivo pharmacodynamic studies of cardiovascular drugs. There are several key considerations in animal model selection as follows.

• Physiological Similarity
  The cardiovascular anatomy and physiology of animal models should be very similar to that of humans.
• Genetic and Molecular Homology
  The genetic and molecular mechanisms involved in the corresponding cardiovascular disease should be similar to those in humans.
• Reproducibility and Reliability
  The animal model should produce consistent, reliable results that can be reproduced in different studies.

Fig. 1 Animal models of atherosclerosis for evaluation of drug effects. (Rom O, et al., 2022)

Ace Therapeutics can provide in vivo pharmacodynamic study solutions for a wide range of cardiovascular drugs, helping clients determine the effective dose range of cardiovascular drugs as well as preclinical pharmacodynamic indicators.

Selection of Animal Models

When conducting in vivo efficacy studies, it is necessary to give due consideration to the sensitivity of the animal model species to tested drugs. We can provide clients with the following animal models of cardiovascular diseases and conduct in vivo pharmacodynamic studies.

Dosage Regimen

We can set the dosage and dosing interval of tested cardiovascular drugs according to the in vitro test results, the effective dose of similar drugs and the pre-test results.

In Vivo Pharmacodynamic Study of Cardiovascular Drugs

Pharmacodynamic evaluation of cardiovascular drugs typically involves assessing the drug's effects on parameters such as heart rate, blood pressure, cardiac output, vascular resistance, and other relevant biomarkers to determine whether the drugs have the desired therapeutic effect on the cardiovascular system.

• Mechanisms of Drug Action
  Preclinical pharmacodynamic studies often involve the study of the mechanism of cardiovascular drug action, such as finding the drug's receptor-binding targets and its effect on signaling pathway transduction.
• Hemodynamic Parameters Assessment
  Hemodynamic parameters such as heart rate, blood pressure, and cardiac output are often tested in pharmacodynamic studies of cardiovascular drugs.
• Cardiovascular Biomarker Assessment
  Cardiovascular biomarkers have good predictive and feedback effects on many cardiovascular diseases. Detecting changes in cardiovascular biomarkers is a direct and effective method when evaluating the efficacy of cardiovascular drugs.

Ace Therapeutics is a contract research organization specializing in the preclinical study of cardiovascular drugs. We can provide professional solutions for in vivo pharmacodynamic studies of different types of cardiovascular drugs. If you are interested in our services, please don't hesitate to contact us.

1. Rom, O.; et al. Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis. Redox Biol. 2022, 52:102313.