Custom Animal Models of Cardiovascular Infection

Inquiry

Infections of the cardiovascular system can be caused by irritants such as bacteria, viruses, and fungi. There are various types of cardiovascular infections, such as endocarditis, myocarditis, and pericarditis, as well as systemic infections such as sepsis. Ace Therapeutics has long been involved in the research of cardiovascular disease animal models, and is experienced in the development of various animal disease models. We are able to provide customized animal models of cardiovascular infections according to the specific requirements of our clients, which is helpful for basic research and drug discovery of cardiovascular diseases.

Overview of Cardiovascular Infections and Their Animal Models

When infected by causative agents such as bacteria, viruses, mycoplasma, chlamydia, and rickettsia, many types of infectious cardiovascular diseases may be induced, including infective pericarditis, infective myocarditis, infective endocarditis, infective heart valve disease, and infective vasculitis. In severe cases, multiple organ concurrent infections or even systemic infections can be induced, which can be life-threatening in severe cases. Nowadays, in the study of cardiovascular infectious diseases, animal models of infective endocarditis are usually obtained using MRSA-infected animals, while models of infective myocarditis are obtained using coxsackievirus and enterovirus EV71 induced. In addition, LPS-induced animal models of systemic inflammation have been widely used for systemic infectious sepsis secondary to cardiovascular infection.

Fig. 1 Clinical Presentation of Acute Myocarditis. (Williams JL, et al., 2023)

Our Services

Ace Therapeutics provides custom animal model development services for a variety of infectious cardiovascular diseases, including but not limited to:

Infective Endocarditis Infectious Myocarditis Systemic Infection

Animal Models of Infective Endocarditis

Overview
We can surgically cannulate the carotid artery in experimental animals, causing endocardial injury. After that, a bacterial endocarditis model is established 24 hours after surgery by intravenous injection of Staphylococcus aureus, Streptococcus, Enterococcus, etc.
Available Animal Species and Strains
Rats (SD rats, Wistar rats), rabbits (New Zealand white rabbit, Japanese white rabbit)
Animal Model Validation
1 week after the injection of bacterial infection, we will examine and isolate the aortic valve and the ventricular cavity for the formation of redundant organisms to determine whether the model has been successfully established.

Animal Models of Infectious Myocarditis

Overview
We can use intraperitoneal injection of coxsackievirus for infecting experimental animals to induce the construction of a viral myocarditis model.
Available Animal Species and Strains
Mice (C57BL/6 mice, BALB/c mice), rats (SD rats, Wistar rats)
Animal Model Validation
After 1 week of modeling, we will examine the viral titer in the myocardial cells of the animal model and observe the myocardial tissues of the model animals by HE staining of pathological sections to determine whether the animal model of viral myocarditis is successfully constructed.

Animal Models of Systemic Infection

Overview
We construct animal models of sepsis, septic shock and multiple organ dysfunction syndrome by injecting LPS into experimental animals to induce a systemic inflammatory response.
Available Animal Species and Strains
Mice (C57BL/6 mice, BALB/c mice), rats (SD rats, Wistar rats), rabbits (New Zealand white rabbit, Japanese white rabbit)
Animal Model Validation
24 hours after modeling of LPS injection, we will examine the expression levels of IL-1β, IL-6, and TNF-α in the blood of experimental animals to determine whether a systemic acute inflammatory response has occurred.

Ace Therapeutics has been committed to cardiovascular disease research for many years, and has a professional scientific research team and a well-established technology platform for animal disease model development to provide professional animal disease model construction services to meet the needs of customers in cardiovascular disease research on animal disease models. In addition, our animal models can be widely used in pharmacodynamic, pharmacokinetic, and toxicological studies. If you are interested in our services, please don't hesitate to contact us.

Reference

Williams, J.L.; et al. Pediatric myocarditis. Cardiol Ther. 2023,12(2):243-260.

! All of our services and products are intended for preclinical research use only and cannot be intended for any clinical use.

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