Custom Animal Models of Arrhythmia
Inquiry
A heart arrhythmia is an abnormality in the rhythm, origin, conduction velocity, or sequence of excitation of a heartbeat. Ace Therapeutics is dedicated to the development of custom animal models and can provide customers with various types of animal models of arrhythmia.
Overview of Animal Models of Arrhythmia
Most of the current antiarrhythmic drugs have arrhythmogenic effects in the treatment of arrhythmias, or can cause other cardiovascular diseases. The development of new antiarrhythmic drugs is of great significance, while the construction of effective animal models of arrhythmia is essential for the development of new drugs. At present, the most commonly used experimental animals for arrhythmia research are mice and rats, which are similar to human beings in terms of cardiac anatomy and physiopathology, and are therefore suitable for the study of arrhythmia pathogenesis and drug development.
Fig. 1 Schematic of the cardiac conduction system and clinical classification of cardiac arrhythmias. (Blackwell DJ, et al., 2022)
Our Services
Ace Therapeutics offers the following development services of animal models of arrhythmia, including but not limited to:
Drug Induced Models
Electrical Stimulation Induced Models
Surgically-Induced Models
Animal Models of Arrhythmias Induced by Drugs
- Overview
Animal models of drug-induced arrhythmias have the advantages of easy control of experimental conditions, short modeling time, and stable symptoms in experimental animals. We are able to build arrhythmia models with drugs such as aconitine, cardiac glycosides, calcium chloride, verapamil, and propranolol according to the customized needs of our clients.
- Available Animal Species and Strains
Mice (C57BL/6 mice, BALB/c mice), rats (SD rats, Wistar rats)
- Animal Model Validation
Since experimental animal models of arrhythmia induced by different drugs are highly variable, we will monitor the electrocardiograms of experimental animals at different time intervals to determine whether the arrhythmia model is successfully constructed.
Animal Models of Arrhythmias Induced by Electrical Stimulation
- Overview
We can increase the release of acetylcholine by electrically stimulating the vagus nerve in experimental animals, thus slowing down the heart rate of animal models. Animal models of arrhythmia induced by electrical stimulation are easy to control, which is one of the most commonly used methods for constructing animal models of bradyarrhythmia.
- Available Animal Species and Strains
Mice (C57BL/6 mice, BALB/c mice), rats (SD rats, Wistar rats)
- Animal Model Validation
After modeling the experimental animals with electrical stimulation, we will monitor them with electrocardiograms to confirm the presence of arrhythmias in the experimental animals.
Animal Models of Arrhythmias Induced by Surgery
- Overview
We can construct animal models of ischemia-reperfusion arrhythmia by applying coronary artery ligation to the sinus node region of experimental animals.
- Available Animal Species and Strains
Mice (C57BL/6 mice, BALB/c mice), rats (SD rats, Wistar rats)
- Animal Model Validation
After coronary ligation of the experimental animals, we will perform ECG monitoring to confirm the presence of arrhythmias in the experimental animals.
Ace Therapeutics has been working in the field of cardiovascular disease for many years. We can design customized animal models of arrhythmia according to our clients' individual experimental needs, which can support the study of pathogenesis, the discovery of novel biomarkers, and the development of novel therapeutic approaches for arrhythmia. If you are interested in our services, please don't hesitate to contact us.
Reference
- Blackwell, D.J.; et al. Animal Models to Study Cardiac Arrhythmias. Circ Res. 2022, 130(12): 1926-1964.
! All of our services and products are intended for preclinical research use only and cannot be intended for any clinical use.
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