In Vivo Efficacy Testing of IBD Drugs

Once a potential drug candidate has demonstrated its efficacy through a series of in vitro tests, it can be tested in vivo. In vivo efficacy studies are a core component of breakthrough drug development, and animal models of inflammatory bowel disease (IBD) provide a critical pathway to successful drug discovery. The results of in vivo efficacy studies are often used as a threshold criterion for determining whether a therapeutic candidate will progress through the drug development process.

Fig. 1. Experimental design schematic for a chronic model of ulcerative colitis induced by DSS in mice (C57BL/6). (Holman et al., 2023)

Our Preclinical Efficacy Services

At Ace Therapeutics, we offer a wide range of IBD animal models for efficacy studies, either as chemical-induced models, T cell transfer models or genetically engineered models of IBD. Our efficacy testing platform provides clients with study designs which are individually tailored to their needs within a reasonable timeframe, indicating a proof of concept or therapeutic efficacy validation.

Ace Therapeutics offers a comprehensive and diverse range of in vivo efficacy evaluation services.

• Assessment of Disease Activity Index (DAI) scores
• Assessment of colon length and weight
• Colonoscopy in IBD animals
• Histological and immunohistochemical evaluation of intestinal tissue
• Inflammatory marker assessment (ELISA, MSD, Luminex, CBA)
• Oxidative stress marker assessment
• Intestinal permeability measurement
• Myeloperoxidase (MPO) analysis in colon tissue
• Transcriptome analysis (RNAseq, ChipSep, miRNA)
• In vivo imaging
• Detection of gene expression in the colon by qPCR/dPCR
• Cell isolation and purification from IBD animals
• Flow cytometric analysis of cells within the intestinal lamina propria

Simplify and Power Your IBD Drug Development

Support and streamline the benefits of your scientific research with an experienced scientific team:

• Rapid study start-up to accelerate your drug development timeline.
• Efficiently integrated research platforms for in vivo imaging, biomarkers, flow cytometry and histopathology analysis.
• Fast and stable experimental data with detailed reports customized to individual study needs.
• Customized model development with a team of researchers with well-established technical skills and scientific expertise.

Ace Therapeutics uses reliable and accurate animal models of IBD to help clients evaluate new drugs and therapies, providing valuable data on disease mechanisms and potential treatment options. If you are interested in our services, please do not hesitate to contact us.