Assessment of Disease Activity Index (DAI) in IBD Animal Models

The Disease Activity Index (DAI) is a commonly used index to assess disease severity in animal models of inflammatory bowel disease (IBD). The index typically consists of multiple parameters, such as weight loss, fecal consistency, rectal bleeding, and the overall animal health. By combining the scores for each parameter, researchers can calculate a total DAI score for each animal, allowing for a consistent and objective assessment of disease severity in animal models of IBD. This can help researchers determine whether modeling has been successful, assess the effectiveness of potential treatments and interventions for IBD, and understand the underlying mechanisms of the disease.

Fig. 1. DAI scores of the animals in the control, sham and colitis groups. (Evangelinellis et al., 2022)

Our DAI Assessment Service

Ace Therapeutics offers high-quality DAI assessment services to help clients evaluate disease severity and drug efficacy in IBD animal models. Our team of professionals has the experience and expertise to rigorously observe and record all animals on a daily basis for general condition, weight change, fecal consistency, fecal occult blood, and scoring according to the following DAI scale. We ensure that you receive reliable DAI data.

DAI = (Weight loss score + Stool consistency + Degree of blood in stool) / 3. An increase in the Disease Activity Index score is an important manifestation of modeling success because weight loss, symptoms of diarrhea, and bloody stools can reflect the injury severity of the digestive tract.

Table 1. Scoring of the disease activity index (DAI)

Why Choose Us

• Expertise and experience. Our team of conscientious professionals has the expertise to provide accurate and precise DAI assessments.
• Detailed raw data records. Our labs have strict lab record requirements to ensure that our assessments meet the highest standards of accuracy and reliability.
• Customized services. We offer customized DAI assessment services to meet the specific needs of our clients. Whether it's customizing the scoring system or incorporating additional parameters, our team works closely with clients to provide personalized and comprehensive services.
• Timely and efficient results. Our streamlined processes and efficient workflows ensure fast turnaround times without compromising the accuracy and quality of results.

Through Ace Therapeutics' DAI assessment service, we help clients gain a more comprehensive understanding of the level of disease activity in animal models of IBD, design and conduct relevant studies, and evaluate the impact of different therapeutics on disease activity. If you are interested in our services, please do not hesitate to contact us.