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* Please note that all of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Biospecimen Collection & Analysis Services for Gastroenterology and Hepatology Research

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At Ace Therapeutics, our well-established research technology platform is designed to accelerate breakthroughs in gastroenterology and hepatology disease research. Based on a dedicated team of gastroenterology and hepatology specialists, we aim to provide clients with custom biospecimen collection and analysis services.
Types of Gastroenterology & Hepatology Biospecimens We Can Provide

Gastrointestinal & Liver Tissue Samples

We specialize in the collection, sectioning, and preservation of gastrointestinal and liver tissues from animal models, such as mice, rats, rabbits, and non-human primates. Our experts ensure uncompromised sample integrity, delivering pristine specimens for your downstream molecular, histological, or biochemical applications. We offer gastrointestinal and liver tissue from the following disease models:

Gastrointestinal Contents (Fecal Samples)

We offer collection and processing of intestinal contents and fecal samples from laboratory animals. These samples are ideal for comprehensive analysis of gut microbiota composition, microbial metabolites, and other critical biomarkers in gastrointestinal research. Based on intestinal contents and fecal samples of the gastrointestinal tract, we also offer the following services:

Microbial Isolation and Culture
Microbial Genome DNA/RNA Extraction
Microbial Metabolite Extraction

Body Fluid Samples

We help clients collect diverse body fluid specimens from animal models, including blood, digestive fluids (gastric, bile, intestinal fluids), saliva, and urine. These obtained samples enable measurement of biomarkers, biochemical parameters, and pathophysiological parameters.

Plasma/Serum Isolation
Exosome Isolation
Cytokine/Antibody Enrichment

Cell Samples

We offer different types of hepatocytes, intestinal epithelial cells, and other cell lines. These well-characterized cellular models serve as invaluable tools for in vitro studies of gastrointestinal and hepatic disorders.

Intestinal Epithelial Cells (Caco-2, HT-29)
Gastric Epithelial Cells (AGS, GES-1)
Hepatocellular Carcinoma Cells (HepG2, Huh-7, HepaRG)

What Can We Do for Gastroenterology and Hepatology Biospecimen Analsis?

Specialized Analytical Services with Gastrointestinal Biospecimens Specialized Analytical Services with Liver Biospecimens

Histopathological Evaluation of Inflammatory Bowel Disease (IBD)

H&E Staining Services: Quantitative assessment of the severity of inflammation in gastrointestinal tissue samples (crypt architecture distortion, inflammatory infiltration density).
Periodic Acid-Schiff (PAS) Staining Services: Assessing mucosal barrier integrity (mucus layer thickness) of gastrointestinal biospecimens.
Masson's Trichrome Staining Services: Detecting and assessing fibrosis quantification (collagen deposition patterns) in gastrointestinal tissue samples.

Mechanism Analysis of Immune-Mediated Enteropathies

Immunohistochemistry/Immunofluorescence Services: Analyzing the spatial distribution of immune infiltrates (CD3+ T cells, CD68+ macrophages) in gastrointestinal biospecimens.
Cytokine Profiling Services: High-sensitivity quantification of pro-inflammatory mediators (IL-1β, TNF-α, IL-6) in gastrointestinal biospecimens via qPCR/ELISA.

Gut Microbiome Analysis and Metabolism Studies

Microbiome Analysis Services: 16S rRNA metagenomic sequencing of gut contents for microbial diversity and dysbiosis indices research.
Microbial Metabolomics services: LC-MS-based detection of gut microbiota-derived metabolites (SCFAs, bile acids) from matched fecal samples.

Metabolomic Profiling of Liver

Metabolomic Analysis of Liver Tissues: We offer comprehensive metabolomics analysis (LC-MS/GC-MS) of liver tissue to identify dysregulated pathways (e.g., lipid metabolism, glucose homeostasis).
Integration with gut microbiome data allows us to help clients understand metabolic liver diseases (NAFLD, cirrhosis) from a multi-omics perspective.

Gut-Liver Axis Mechanism Studies

Bile Acids Analysis Services: We can quantify primary/secondary bile acids in liver and paired intestinal samples using TLC/LC-MS.
Gut–Liver Axis Study: Elucidating gut-liver interactions by analyzing microbiome-metabolite correlations.

Viral Hepatitis Biomarker Identification Services

Serological Testing: We can provide quantitative detection of HBsAg, anti-HCV, HBV DNA/RNA from blood samples.
Liver Tissue Examination: Analyzing the pathological process of viral hepatitis and monitoring drug efficacy by detection and localization of viral load in liver biospecimens using the PCR-ISH method.

Ace Therapeutics is a specialized research service provider dedicated to advancing research in gastrointestinal and liver diseases. By leveraging our scientific expertise, we empower researchers and pharmaceutical companies to overcome complex challenges in this field. Contact us today to discuss how we can support your specific research objectives.

Our products and services are for research use only and can not be used for diagnostic or other purposes.