Preclinical Ophthalmic Drug Development Services ace

Microneedle-Based Ocular Drug Delivery System Development Services

The advent of microneedle ocular delivery systems has revolutionized ophthalmic disease treatment. As a comprehensive ophthalmic solution CRO, Ace Therapeutics is committed to providing global customers with leading technical support and services for the development of microneedle ocular delivery systems. Our highly qualified researchers will customize and develop the most appropriate solution according to your needs. This includes preparation of microneedles, characterization of microneedles, biosafety assessment, in vivo studies of ocular drug delivery, etc.

Development of a Microneedle Drug Delivery System for Ocular Disease

Advantages of Microneedle for Ocular Delivery Systems

The key to ophthalmic drug development is drug delivery to designated ocular tissues, especially the posterior segment of the eye. An effective drug delivery system to the back of the eye would help control these sight-threatening diseases. Traditional drug delivery relies on subcutaneous injections, eye drops, and oral pills to deliver the drug to the retinal tissue at the back of the eye. However, these methods are highly invasive, have high side effects, and poor targeting, and limited sustained release capabilities. As a novel ocular drug delivery system, microneedles are considered a painless, noninvasive, and efficient alternative for transdermal, intradermal, and transdermal drug delivery. It minimizes damage to the eye, reduces disruption of membrane continuity, makes drugs more effective, and reduces complications. In addition, it can target drugs to the retina, choroid, and other structures at the back of the eye. That said, microneedles offer a whole new opportunity to develop very complex and precise ocular drug delivery tools.

DFig. 1. Ocular anatomic barriers and routes of drug administration. Fig. 1. Ocular anatomic barriers and routes of drug administration. (Gadziński P, et al., 2022)

What Is Ace Therapeutics Doing for Ocular Drug Delivery System Development?

Microneedles offer a promising means for sustainable ocular drug delivery. In recent years, Ace Therapeutics has made significant achievements in the microneedle ocular drug delivery system. Our talented researchers are committed to developing the leading ocular microneedle delivery system to serve researchers worldwide.

For anterior segment corneal diseases, Ace Therapeutics' development strategy focuses on microneedle patches; for posterior ocular diseases, we provide a non-invasive micro-drug reservoir delivery system that replaces vitreous injections, which greatly avoids cross-eye Ministry of stimulation.

One-stop Microneedle Drug Delivery System Development Service for Ocular Disease

Ace Therapeutics stocks a variety of common materials for microneedle fabrication, including silicon, ceramics, metals, biodegradable polymers, and non-biodegradable polymers. Using fabrication methods such as lithography or laser technology, casting, and 3D printing, our researchers explored a variety of microneedle modalities, including microneedle patches for corneal penetration and microneedle injections targeting the back of the eye for drug delivery.

At Ace Therapeutics, we provide one-stop microneedle eye delivery system development services to global customers, including but not limited to:

Preparation of microneedles
Characterization of microneedles
Biosafety assessment
In vivo studies of ocular drug delivery

Our Capabilities

Additionally, Ace Therapeutics offers the following other ocular delivery systems that may be of interest to you, ask our scientists for details.

As a contract provider of solutions for ocular diseases, in order to better understand unmet needs, successful delivery of ocular drug delivery systems. Ace Therapeutics can provide our customers with one-stop Microneedle ocular delivery system development services. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

Gadziński P, Froelich A, Wojtyłko M, et al. Microneedle-based ocular drug delivery systems - recent advances and challenges. Beilstein J Nanotechnol. 2022 Oct 24;13:1167-1184.
Thakur Singh RR, Tekko I, McAvoy K, et al. Minimally invasive microneedles for ocular drug delivery. Expert Opin Drug Deliv. 2017 Apr;14(4):525-537.

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