Preclinical Ophthalmic Drug Development Services ace

Liposomal Ocular Drug Delivery System Development Services

Liposomes have been favored by many developers of ophthalmic products as an effective non-invasive ocular delivery system. As a full-scale ophthalmic solution CRO, Ace Therapeutics aims to provide our customers with one-stop liposome ocular delivery system solutions, including liposome preparation, liposome characterization, ophthalmic drug delivery, efficacy evaluation, etc. We believe groundbreaking research and state-of-the-art equipment will develop ocular liposome formulations and products like no other.

Development of a Liposome Drug Delivery System for Ocular Disease

Advantages of Liposomes for Ocular Delivery Systems

Liposomes, one of the promising nanosystems for ocular drug delivery, have been successfully translated into nano-drug delivery systems for real-time clinical applications. It consists of a cell membrane-like lipid bilayer surrounding an aqueous phase, characterized by a lipid bilayer with an internal aqueous cavity. Liposome structural components are phospholipids or synthetic amphiphiles that bind to sterols such as cholesterol to affect membrane permeability. Thin-film hydration is the most widely used liposome preparation method, in which the lipid component, with or without the drug, is dissolved in an organic solvent. Because of its ability to increase the residence time of drug absorption, prolong the half-life of the drug in the vitreous, and its own low toxicity, it represents a promising ocular drug delivery system for delivering drugs to the posterior segment of the eye chamber (retina/choroid) and is an excellent non-aggressive means.

Fig. 1. Schematic representation of basic structures and different types of liposomes. (Bhattacharjee A, et al., 2017)

What Is Ace Therapeutics Doing for Ocular Drug Delivery System Development?

Delivery of drugs/drug candidates to the posterior segment of the eye is extremely challenging. As one of the global leaders in eye disease solutions, Ace Therapeutics is committed to providing leading liposome ocular delivery system development services to global researchers and pharmaceutical companies. Here, you will benefit from our experienced team of experts in ophthalmology and nanomaterials to advance your compound candidates. We are always confident that our services will be of the highest standard and meet all your project development needs.

One-stop Liposome Drug Delivery System Development Service for Ocular Disease

With more than ten years' experience in ocular delivery system development, Ace Therapeutics provides one-stop liposomal delivery system development services for ocular drug to our global customers. In addition, our talented scientists select the most appropriate preclinical ocular disease translational model to evaluate your product's therapeutic efficacy. In order to meet the different needs of global researchers, our expert team will choose different liposome preparation methods according to customers' needs, including film hydration method, double emulsion method, solvent injection method, and in situ preparation technology.

Our services include, but are not limited to:

Preparation of liposomes
Liposome analysis
Characterization of liposomes
In vitro cell evaluation
Corneal permeability assessment
Early ocular pharmacodynamic assessment
Ocular irritation assessment
Live animal models of ocular disease

Our Capabilities

Additionally, Ace Therapeutics offers the following other ocular delivery systems that may be of interest to you, ask our scientists for details.

As a contract provider of solutions for ocular diseases, in order to better understand unmet needs, successful delivery of ocular drug delivery systems. Ace Therapeutics can provide our customers with one-stop liposome ocular delivery system development services. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

Mishra GP, Bagui M, Tamboli V, et al. Recent applications of liposomes in ophthalmic drug delivery. J Drug Deliv. 2011;2011:863734.
Bhattacharjee A, Das PJ, Adhikari P, et al. Novel drug delivery systems for ocular therapy: With special reference to liposomal ocular delivery. Eur J Ophthalmol. 2019 Jan;29(1):113-126.

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