Advantages of Hydrogels for Ocular Delivery Systems

Hydrogel is an aqueous gel composed of a cross-linked network of hydrophilic polymer chains, with a high water retention capacity. Their properties, such as responsiveness to heat, pH, and light stimuli, are particularly suitable for drug loading with a controlled release mechanism for easy drug delivery. In recent decades, in the field of treatment of ophthalmic diseases, researchers have gradually paid attention to stimuli-responsive hydrogel systems for ocular drug delivery, mainly because hydrogel is a multifunctional ophthalmic drug delivery system that can pass through Changing the drug release profile of the preparation (sustained drug release) prolongs the residence time of the drug and reduces eye irritation from frequent dosing.

Fig. 1. Regions of the eye where hydrogels are currently used. (Cooper RC, et al., 2019)

What Is Ace Therapeutics Doing for Ocular Drug Delivery System Development?

The most common hydrogel formulations for ocular delivery include contact lenses and drug-delivery hydrogels. As the world's leading developer and provider of eye delivery system solutions, Ace Therapeutics is dedicated to improving patients' lives by developing differently from other ocular delivery systems. You only need to tell us your needs, and we will provide you with a series of hydrogel-based drug delivery system development services, including but not limited to:

• Pre-formulation: selection of polymers and cross-linking components and reaction modes.
• Formulation development: preparation of hydrogel, encapsulation, and release of the payload.
• Fabrication: characterization of hydrogels and delivery modes selection.
• Ocular pharmacodynamic evaluation: in vitro cell evaluation and in vivo animal evaluation.

One-stop Hydrogel Drug Delivery System Development Service for Ocular Disease

Designing an ideal ocular therapy or drug delivery platform requires understanding not only how the therapy works, but also the components that make up the vehicle. Ace Therapeutics has a research team with strong expertise in biomaterials, all of whom have decades of experience in the development of ocular hydrogel delivery systems. We provide our global clients with the following hydrogel development services for ocular delivery systems.

• Physical hydrogel
• Chemically bonded hydrogel
• Stimuli-responsive and in situ hydrogel systems
• Temperature-sensitive hydrogel system
• PH-sensitive hydrogel system
• Ion-sensitive hydrogel system
• Ultrasound-responsive hydrogel system

Ace Therapeutics' Hydrogel Ocular Delivery System Development Platform

• Chitosan Polymer Biological Platform
• Hyaluronic Acid Polymer Platform
• Gelatin Polymer Platform
• Alginate Polymer Platform
• Methyl Cellulose Polymer Platform
• Collagen Polymer Platform

Our Capabilities

Additionally, Ace Therapeutics offers the following other ocular delivery systems that may be of interest to you, ask our scientists for details.

• Solid Lipid Nanoparticle Development Services for Ocular Drug Delivery
• Development Services for Liposomal Ocular Drug Delivery Systems
• Dendrimer Nanoparticle Development Services for Ocular Drug Delivery
• Development Services for Nanomicelle-Based Ocular Drug Delivery Systems
• Development Services for Microneedle-Based Ocular Drug Delivery Systems
• Ocular Implant Development Services for Drug Delivery
• Ocular Insert Development Services for Drug Delivery

As a contract provider of solutions for ocular diseases, in order to better understand unmet needs, successful delivery of ocular drug delivery systems. Ace Therapeutics' talented research team provides efficient hydrogel ocular delivery system development services for global customers. If you are interested in our services or need more detailed information, please feel free to contact us. Our experienced scientists are ready to help you!

References

1. Cooper RC, Yang H. Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations. J Control Release. 2019 Jul 28;306:29-39.
2. Lynch CR, Kondiah PPD, Choonara YE, et al. Hydrogel Biomaterials for Application in Ocular Drug Delivery. Front Bioeng Biotechnol. 2020 Mar 20;8:228.

• Solid Lipid Nanoparticle Development Services for Ocular Drug Delivery
• Liposomal Ocular Drug Delivery System Development Services
• Dendrimer Nanoparticle Development Services for Ocular Drug Delivery
• Nanomicelle-Based Ocular Drug Delivery System Development Services
• Microneedle-Based Ocular Drug Delivery System Development Services
• Ocular Implant Development Services for Drug Delivery
• Ocular Insert Development Services for Drug Delivery

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