Inducible Animal Models of Glaucoma

At Ace Therapeutics, our team of glaucoma experts has the experience and expertise to conduct high-quality studies that align with your research objectives. As a trusted contract research service provider, we specialize in offering comprehensive preclinical solutions for glaucoma research, ranging from basic research to drug development.

Background on Inducible Animal Models of Glaucoma

Glaucoma is a leading cause of irreversible blindness worldwide, characterized by the progressive loss of retinal ganglion cells (RGCs) and damage to the optic nerve. Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, and most preclinical models are designed to recapitulate this condition to study its effects on RGCs and visual function. However, not all cases of glaucoma are IOP-dependent. For example, normal tension glaucoma (NTG) occurs without elevated IOP, highlighting the importance of IOP-independent mechanisms (e.g., vascular dysregulation, oxidative stress) in disease progression. This complexity underscores the need for diverse animal models that can simulate both IOP-dependent and IOP-independent forms of glaucoma.

Fig. 1 Summary of the differences between the IOP-dependent and non-IOP dependent component of primary open angle glaucoma (POAG). (Huang Y, et al., 2024)

Get to Know Our Inducible Models of Glaucoma

Animal models are indispensable for elucidating disease mechanisms, screening neuroprotective agents, and evaluating novel therapeutics. Ace Therapeutics offers a robust portfolio of inducible glaucoma models, validated through rigorous protocols and supported by multimodal outcome assessments.

IOP-Dependent Animal Models of Glaucoma

We specialize in developing IOP-dependent animal models of glaucoma, designed to simulate the pathological effects of elevated IOP on RGCs and optic nerve health.

• Custom Microbead-Induced Glaucoma Models
• Custom Carbomer-Induced Glaucoma Models
• Custom Hyaluronic Acid-Induced Glaucoma Models
• Custom Hypertonic Saline-Induced Glaucoma Models
• Custom Laser Photocoagulation-Induced Glaucoma Models
• Custom Episcleral Vein Cauterization and Ligation-Induced Glaucoma Models
• Custom Circumlimbal Suture-Induced Glaucoma Models
• Custom Glucocorticoid-Induced Glaucoma Models
• Custom ET-1-Induced Glaucoma Models

IOP-Independent Animal Models of Glaucoma

We provide IOP-independent animal models designed to investigate glaucoma mechanisms and evaluate drug development that do not rely on elevated IOP.

• Custom Optic Nerve Crush and Transection-Induced Glaucoma Models
• Custom Retinal Ischemia-Reperfusion Injury-Induced Glaucoma Models
• Custom Excitatory Amino Acid-Induced Glaucoma Models
• Custom TNF-α-Induced Glaucoma Models

Applications of Inducible Animal Models for Glaucoma Research

Our inducible animal models of glaucoma are ideal for:

• Disease modeling
  Simulate various forms of glaucoma to identify potential therapeutic targets.
• Mechanistic studies
  Investigate the molecular and cellular pathways underlying glaucoma.
• Efficacy evaluation
  Evaluate the efficacy of novel drugs.

Why Choose Ace Therapeutics

Ace Therapeutics' team of glaucoma experts has extensive experience in developing a variety of animal models for glaucoma research as well as evaluating of drug efficacy, safety, and pharmacokinetic properties. By choosing us, you gain access to:

• Customized solutions
• Technical support
• One-stop services

Whether you are investigating IOP-dependent or IOP-independent mechanisms, Ace Therapeutics provides a range of inducible animal models and services designed to support your preclinical studies. Contact us to learn more about our diverse inducible animal models of glaucoma and how they can support your research.

References

1. Ishikawa M, et al. Experimentally Induced Mammalian Models of Glaucoma. Biomed Res Int, 2015, 2015: 281214.
2. Huang Y, et al. GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma. Nat Commun, 2024, 15(1): 8962.