As a trusted preclinical partner, Ace Therapeutics is dedicated to constructing preclinical animal models to support your glaucoma research. Our laser photocoagulation-induced glaucoma models can be served as a reliable platform to help you explore disease mechanisms, evaluate neuroprotective agents and intraocular pressure (IOP)-lowering therapeutics.
About Laser Photocoagulation-Induced Glaucoma Models
Laser photocoagulation-induced glaucoma models are essential tools for studying the pathophysiology of glaucoma. By applying laser photocoagulation to the trabecular meshwork (TM) or episcleral veins, these models obstruct the aqueous humor outflow pathway, leading to sustained IOP elevation. This method offers a controlled way to induce ocular hypertension (OHT) and neuroretinal damage, effectively mimicking human glaucoma. By targeting specific retinal regions, laser photocoagulation allows controlled levels of neurodegeneration, making it ideal for studying chronic disease stages and therapeutic interventions. These models are highly reproducible, non-invasive, and suitable for long-term studies.
Fig. 1 Methods of laser-induced chronic ocular hypertension (COHT) model. (Sun D F, et al., 2022)
Explore Our Laser Photocoagulation-Induced Glaucoma Models
We offer a comprehensive suite of services centered around custom laser photocoagulation-induced glaucoma models to support your research needs.
Customizable Laser-Induced Glaucoma Models
- Focal laser photocoagulation
We provide selective laser targeting of the retinal vasculature or TM to induce localized IOP elevation. - Panretinal photocoagulation (PRP)
We offer widespread laser application to simulate advanced glaucoma with extensive retinal ganglion cell (RGC) loss. - Chronic OHT models
We provide repeated low-intensity laser treatments to mimic gradual IOP fluctuations and sustained neurodegeneration.
Key Features of Our Laser-Induced Glaucoma Models
- Tunable IOP elevation
Our scientists can adjust laser parameters (energy, duration, spot count) to achieve a range of mild-to-severe OHT profiles. - Controlled neurodegeneration
By histopathology and imaging, we can quantify RGC loss and axonal damage.
Advantages of Our Laser-Induced Glaucoma Models
- High reproducibility
- Human disease relevance
- Versatility
Laser Photocoagulation-Induced Glaucoma Model Evaluation Services
- Assessment of RGC function
Using techniques such as pattern electroretinogram (PERG) and photopic negative response (PhNR) of the full-field ERG, we provide RGC function assessment services. - Structural analysis
Our team can perform detailed histological and immunohistochemical analyses to evaluate retinal ganglion cell loss, optic nerve damage, and changes in the extracellular matrix. - Detection of inflammatory and fibrotic markers
We offer detection of inflammatory cell markers and fibrotic markers to study the underlying mechanisms of IOP elevation.
Ace Therapeutics is comprised of experienced researchers and scientists with a deep understanding of glaucoma pathophysiology and modeling techniques. We provide customized solutions tailored to your specific research needs, ensuring that our models and services are aligned with your goals. Interested in exploring how our laser photocoagulation models can support your glaucoma research? Contact us to discuss your project and discover the possibilities!
Reference
- Sun D F, et al. Protocol for laser-induced chronic ocular hypertension and intracameral injection in nonhuman primates. STAR Protoc, 2022, 3(4):101801.