Ace Therapeutics provides specialized services for constructing in vitro trabecular meshwork (TM) cell models to support glaucoma research.
Introduction into Trabecular Meshwork
The TM cells are involved in assisting maintenance of aqueous humor (AH) across the trabecular lamellae and secretion of extracellular matrix, specific enzymes and phagocytosis of excreted debris from the AH. The TM plays a crucial role in regulating intraocular pressure (IOP) by controlling the outflow of AH. Changes in the physicochemical properties of the TM can significantly impact AH outflow, potentially leading to elevated IOP and resulting in optic nerve damage.
Fig.1 Location of the trabecular meshwork (TM). (Bikuna‐Izagirre M, et al., 2022)
Trabecular Meshwork Cell Model Construction Services
At Ace Therapeutics, we specialize in providing customized TM cell modeling services designed to support researchers in studying the physiological and pathological functions of TM cells.
- Custom 2D Trabecular Meshwork Cell Models
We are committed to constructing 2D TM cell models that closely mimic the natural properties of TM. These models serve as a reliable platform for studying the cell responses of TM cells to various pharmacological agents. By utilizing our 2D TM cell models, clients can evaluate the effects of potential treatments on TM function, facilitating the screening and identification of effective therapeutic agents for glaucoma.
- Photolithography
Photolithography allows you to control pore size and shape, and can be used directly to generate a culture substrate. - Traditional Polymeric Filters
Our filters of different materials can be used as TM scaffolds to study AH outflow.
- Custom 3D Trabecular Meshwork Cell Models
We offer 3D TM cell model construction services to provide appropriate in vitro models for glaucoma research. Our experts utilize diverse technologies, such as electrospinning technique and 3D bioprinting, to fabricate 3D scaffolds tailored to specific research requirements, and our 3D TM cell models enable researchers to investigate the biological and physiological issues related to glaucoma.
- Electrospinning Technique
We employ electrospinning technology to fabricate nanofibrous scaffolds, which can mimic the fibrous structure of the natural TM, ensuring high porosity and excellent cell attachment properties. - 3D Bioprinting
With 3D bioprinting technology, our experts can construct complex 3D structures, enabling high-resolution and high-precision model manufacturing. - Hydrogel Molding
Utilizing hydrogel molding technology, we fabricate 3D scaffolds with adjustable pore sizes and mechanical properties, which can mimic the mechanical environment of the natural TM.
Applications of Trabecular Meshwork Cell Models
- Evaluate the efficacy of new IOP-lowering drugs.
- Investigate the mechanism underlying TM dysfunction.
- Simulate AH outflow mechanisms.
By simulating the structure and function of native TM, Ace Therapeutics' models provide valuable insights into AH outflow mechanisms, drug screening processes, and the pathophysiology of glaucoma. Contact us if you are interested in our in vitro TM cell models.
Reference
- Bikuna-Izagirre M, et al. Technological advances in ocular trabecular meshwork in vitro models for glaucoma research. Biotechnol Bioeng, 2022 Oct; 119(10): 2698-2714.