Stroke Drug Preclinical Evaluation Services

Stroke is one of the most devastating neurological diseases. There is an urgent need to develop drugs for the treatment of ischemic stroke and hemorrhagic stroke therapy. Preclinical development is one of the research and development processes that must be carried out before a new drug can be marketed. Pharmaceutical companies need to perform all the activities of drug discovery prior to the clinic to ensure that the drug is ready for human clinical trials. In vitro and in vivo laboratories conduct preclinical studies to determine target efficacy, potential side effects, feasibility testing, drug safety assessment, etc. Depending on the preclinical results, scientists can either work to eliminate or minimize the side effects of the drug to bring the drug to the clinical stage or abandon the drug to minimize losses.

Our Preclinical Contract Research Services for Stroke Drugs

Ace Therapeutics is a leading preclinical CRO in the field of stroke research, supporting pharmaceutical companies in their preclinical development programs for stroke drugs. Our experienced team of scientists has years of experience in designing and conducting preclinical studies of stroke drugs, and we are committed to providing our clients with the highest quality data and support.

Our preclinical testing services support your preclinical development from target to IND, covering a wide range of studies designed to evaluate the safety and efficacy of your stroke drugs. With state-of-the-art facilities and cutting-edge preclinical testing technology, we offer a broad portfolio of in vitro and in vivo testing options. If the study design requires direct hands-on involvement, we can customize the design plan and work side-by-side with your scientists.

ADME/DMPK Services for Stroke Drugs

At Ace Therapeutics, we have built an experienced DMPK drug discovery team that can help you design the optimal ADME DMPK program for your stroke drug discovery and development needs. discovery and development needs. Our ADME DMPK services include:

• High Throughput ADME Screening
• In Vitro ADME
• In Vivo ADME
• PK/TK Analysis
• BBB PK Analysis
• PK/PD Analysis
• Bioanalysis
• Metabolite Identification and Profiling
• Neurochemistry Assay

Drug Efficacy Testing Services in Animal Models of Stroke

Ace Therapeutics's drug efficacy services use a variety of animal models of stroke to assess the therapeutic potential of drug candidates. We utilize expertise in pharmacology, biochemistry, and molecular biology to design and execute studies to measure the impact of your drug on stroke-related biomarkers and endpoints. Our drug efficacy services include:

• Cerebral Infarct Size Measurement
• Histological Assessment
• Physiological Monitoring
• Behavioral Testing
• Brain Imaging
• Cerebral Blood Flow Monitoring
• Brain Edema Measurement
• Blood-Brain Barrier Disruption Assessment
• Leukocyte-Platelet Aggregates Assessment
• Quantitative Analysis of Stroke-related Protein and mRNA Expression

Safety Assessment Services for Stroke Drug Discovery & Development

Ace Therapeutics's drug safety assessment services are dedicated to evaluating the safety of drug candidates using advanced 3D cellular models and animal models of stroke. Our deep expertise in pharmacology and pathology allows us to design and execute comprehensive studies that measure the effects of your drug on the brain and overall physiologic health. Whether you are developing an innovative small molecule drug or an advanced biologic candidate, you can rely on our safety evaluation team to develop a program that meets your specific needs.

In Vitro Pharmacology Services for Stroke Drugs

After oxygen sugar deprivation, Ace Therapeutics offers a comprehensive range of ischemic stroke in vitro assays to help our clients study stroke pathology and perform test drug screening. Our ischemic stroke in vitro assay service allows for robust, flexible, and customized analysis of test drugs on a wide range of cell lines.

• Cell Viability Assay
• Caspase-3 Activity Assay
• In Vitro Neuroinflammatory Models and Assays
• Excitotoxicity In Vitro Assay
• Cell-Based Mitochondrial Function Assay
• In Vitro Oxidative Stress Assay

Our Capabilities and Strengths

• Expertise: Our team excels in stroke research and has experienced professionals with a wealth of experience and expertise in preclinical studies.
• Study design: We work with our clients to develop the most appropriate study design for their specific objectives.
• Data analysis: We use state-of-the-art methodologies to analyze study data and provide our clients with clear and concise reports.
• Model development: We develop and validate preclinical models of stroke to help our clients understand the potential of their drug candidates.

If you need high-quality preclinical testing services for stroke drugs, partner with Ace Therapeutics. Our experienced team is ready to assist you in designing and executing preclinical studies that meet your specific requirements. Contact us today to discuss your project and learn how our expertise can contribute to your success.