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- BBB DamageCategories
- Neurotransmitter Antibodies & Receptor Antibodies
- Ionotropic Receptor AntibodiesMetabotropic Receptor AntibodiesNeurotransmitter AntibodiesTransporter AntibodiesSignal Channel Antibodies
- Calcium Channel AntibodiesChloride Channel AntibodiesDense-Core Vesicles AntibodiesNitric Oxide Channel AntibodiesStroke Pathology Antibodies
- Neurogenesis AntibodiesNeuronal Growth & Development AntibodiesNeuronal Growth & Development AntibodiesNeuronal Metabolism AntibodiesSignal Transduction AntibodiesStroke-Related Cell Markers Antibodies
- Glial Cell Marker AntibodiesNeural Stem Cell Marker AntibodiesNeuron Marker AntibodiesSynaptic Marker AntibodiesCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
Collagens
Collagen is the main component of connective tissue and is abundant in mammals. It is the most widely used extracellular matrix in 3D cell culture to promote cell attachment, growth, differentiation, migration and tissue morphogenesis.
In the 3D BBB model, collagen is used as the main component of the cell culture matrix to provide a support and attachment matrix for cells, thus supporting the simulation study of complex cell interactions and biological processes.
The 3D BBB model is a three-dimensional cell culture model that simulates the blood-brain barrier and is used to study related neurobiology and drug delivery issues. In order to reproduce real physiological conditions, the 3D BBB model uses a collagen matrix to culture brain vascular endothelial cells and other related cells to form a microenvironment with blood-brain barrier function. Collagen plays different roles when creating a three-dimensional blood-brain barrier (BBB) model culture matrix.
- Has good biocompatibility and can promote cell attachment and growth.
- Has a three-dimensional structure and can simulate the characteristics of real tissues.
- Helps form the structure and function of brain vascular endothelial cells and related cells.
It is worth noting that the choice of collagen for the 3D BBB model culture matrix should be based on the specific requirements of the study and the desired matrix functionality. Furthermore, combining different types of collagen or using mixtures of collagen with other ECM components can further enhance the biomimetic properties and functionality of BBB model culture substrates.
Ace Therapeutics produces and supplies different types of collagen to help you construct an ideal, stable 3D BBB model in vitro that meets your research needs.
Cat.# Name Description Price BBM-3C-031 Human Collagen Type I, 0.1 mg Human Collagen Type I, 0.1 mg from Ace Therapeutics is purified from human placenta. Type I collagen is found in connective tissues and is the major component of tensile strength of the extracellular matrix (ECM). The product is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells, etc. In addition, the product can self-assemble into a 3-D supramolecular gel in vitro as an ideal biological scaffold.inquiry BBM-3C-032 Human Collagen Type II, 0.1 mg Human Collagen Type II, 0.1 mg from Ace Therapeutics is purified from human cartilage.inquiry BBM-3C-033 Human Collagen Type III, 0.1 mg Human Collagen Type III, 0.1 mg from Ace Therapeutics is purified from human cartilage. Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls, and walls of blood vessels, which resembles other fibrillar collagens in structure and function. Type III collagen together with type I collagen are the main constituents of the interstitial matrix.inquiry BBM-3C-034 Human Collagen Type IV, 0.1mg Human Collagen Type IV, 0.1mg from Ace Therapeutics is purified from human cartilage.inquiry BBM-3C-035 Human Collagen Type V, 0.1mg Human Collagen Type V, 0.1mg from Ace Therapeutics is purified from human placenta. Type V collagen, a fibrillar collagen, is critical for the fibrillation of types I and III collagen, contributing to optimal fibril formation and tissue quality.inquiry BBM-3C-036 Rat Tail Tendon Collagen Type I Rat Tail Tendon Collagen Type I from Ace Therapeutics is purified from rat tail by the Birkedal-Hansen method. This product can form a three-dimensional glue with a certain strength when the concentration is above 1mg/mL and the pH is around 7. Note: This product can quickly gel at RT when the pH is neutral. Keep the temperature as low as possible during the operation.inquiry BBM-3C-037 Soluble Collagen Type I Soluble Collagen TypeⅠ from Ace Therapeutics is purified fromBovine achilles tendon by the Birkedal-Hansen method.inquiry BBM-3C-038 Rat Tail Collagen Type I Rat Tail Tendon Collagen Type I from Ace Therapeutics is purified from rat tail by the Birkedal-Hansen method. This product can form a three-dimensional glue with a certain strength when the concentration is above 1mg/mL and the pH is around 7.inquiry BBM-3C-039 Rat Tail Collagen Type I (from Rat Tail Tendon) Rat Tail Collagen Type I (from Rat Tail Tendon) from Ace Therapeutics is purified from rat tail by the Birkedal-Hansen method. This product has the advantages of high purity (SDS-PAGE>85%), low endotoxin, and easy storage and transportation, making it convenient for customers to prepare the required concentration.inquiry BBM-3C-040 Collagen Type IV from Human Cell Culture Collagen Type IV from Human Cell Culture from Ace Therapeutics is derived from human fibroblasts and epithelial cells in a co-culture system, which creates an in vitro ECM (extracellular matrix) and serves as an excellent biological scaffold for three-dimensional cell culture.inquiry BBM-3C-041 Human Collagen Type IV Human Collagen Type IV from Human Cell Culture from Ace Therapeutics is derived from human placenta.inquiry BBM-3C-042 Collagen Type IV (Human Placenta) Collagen Type IV (Human Placenta) from Human Cell Culture from Ace Therapeutics is derived from human placenta and is highly purified native, type IV collagen.inquiry BBM-3C-043 Collagen from Human Placenta Collagen from Human Placenta is used to induce differentiation of endothelial cells and rat pluripotent cells. This product is a lyophilized powder that can be reconstituted at 1 mg/mL in sterile 0.5 M acetic acid, PBS, or water.inquiry BBM-3C-044 Collagen, Type I Solution from Rat Tail Collagen, Type I Solution from Rat Tail from Ace Therapeutics is derived from rat tail, which used in tissue engineering especially in the generation of 3-D scaffolds based gels.inquiry BBM-3C-045 Collagen from Human Placenta Collagen from Human Placenta is supplied as a 0.5 M acetic acid solution. It can be used to coat tissue culture surfaces to promote cell attachmentinquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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