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- BBB DamageCategories
- Neurotransmitter Antibodies & Receptor Antibodies
- Ionotropic Receptor AntibodiesMetabotropic Receptor AntibodiesNeurotransmitter AntibodiesTransporter AntibodiesSignal Channel Antibodies
- Calcium Channel AntibodiesChloride Channel AntibodiesDense-Core Vesicles AntibodiesNitric Oxide Channel AntibodiesStroke Pathology Antibodies
- Neurogenesis AntibodiesNeuronal Growth & Development AntibodiesNeuronal Growth & Development AntibodiesNeuronal Metabolism AntibodiesSignal Transduction AntibodiesStroke-Related Cell Markers Antibodies
- Glial Cell Marker AntibodiesNeural Stem Cell Marker AntibodiesNeuron Marker AntibodiesSynaptic Marker AntibodiesCell Death and ApoptosisNeuroinflammationNeuronal Damage and RepairOxidative StressVascular Mechanisms
- 3D BBB Models
- Organ-on-a-Chip BBB ModelsTranswell Models3D BBB Models Culture Substrate
- 3D HydrogelsCollagensAnmial BBB ModelsCell Lines for BBB Modeling
- Immortalized CellsPrimary CellsStem Cells
3D BBB Models Culture Substrate
The BBB is a specialized barrier in the brain that regulates the entry of molecules and cells from the bloodstream into the brain. It plays a crucial role in protecting the brain from harmful substances and maintaining its homeostasis.
Traditional 2D cell model of BBB culture is performed on simple, nonporous two-dimensional (2D) surfaces. Despite the method being easy and convenient, can result in certain well-documented artifacts. The 3D BBB model culture substrate refers to the three-dimensional culture system used for culturing and studying the blood-brain barrier (BBB) model in vitro, which aims to mimic the physiological conditions of the brain's microenvironment, allowing researchers to study BBB function and dysfunction in a controlled laboratory setting. It typically consists of a specialized culture substrate that supports the growth and differentiation of brain endothelial cells, which form the main component of the BBB. The substrate is often coated with extracellular matrix proteins like collagen or laminin to provide a suitable surface for cell attachment and growth.
A well-established method for culturing 3D BBB models is to culture cells on structural scaffolds, which are typically composed of biopolymers, such as 3D hydrogels and collagens, arranged to mimic the physiological extracellular matrix (ECM).
Highlighted below are the types of brackets Ace Therapeutics offers for 3D BBB model culture.
Click on the Links to Access Our 3D BBB Model Culture Substrate:
Cat.# Name Description Price BBM-3C-102 Collagen Hydrogel (Soft+-Bovine) Collagen Hydrogel from Ace Therapeutics is a biocompatible complex of type I collagen fibers. These products contain a variety of purified, high-quality collagens derived from biological tissues, which facilitate gel formation and help the cultivation of 3D tissue models. When using this type of product for 3D culture, it will not break or tear easily. Collagen Hydrogel (Soft+-Bovine) contains purified collagens from the bovine tendon.inquiry BBM-3C-103 3D Cell Culture Hydrogel (100% Peptide) 3D Cell Culture Hydrogel (100% Peptide) from Ace Therapeutics is a peptide synthetic hydrogel without any animal-derived or bioactive ingredients that can be used as an ideal three-dimensional cell culture scaffold.inquiry BBM-3C-104 3D Cell Culture Scaffold Kit 3D Cell Culture Scaffold Kit, a ready-to-use hydrogel system, is used for creating a three-dimensional (3D) cell culture environment, which contains proprietary 3D scaffolds for setting up spheroid formations, 3D cell cultures, and pharmacological studies.inquiry BBM-3C-105 3D Cell Culture Matrix Kit (Alginate Hydrogel) 3D Cell Culture Matrix Kit (Alginate Hydrogel) is used to artificially create a three-dimensional (3D) cell culture environment. The foundation of this kit is alginate, an anionic polysaccharide sourced from algae cell walls.inquiry BBM-3C-106 3D Cell Culture Matrix Kit (BME) 3D Cell Culture Matrix Kit (BME) is used to artificially create a three-dimensional (3D) cell culture environment. The kit consists of a cell-adhesive matrix with a microporous structure from animal sources.inquiry BBM-3C-107 3D Cell Culture Matrix Kit (Duo-Matrix) 3D Cell Culture Matrix Kit (Duo-Matrix) is used to artificially create a three-dimensional (3D) cell culture environment, providing a more dynamic microenvironment as opposed to a single component matrix.inquiry BBM-3C-108 3D Cell Culture Hydrogels Kit (Peptides) 3D Cell Culture Hydrogels Kit (Peptides) is a synthetic peptide hydrogel free of animal origin, which can simulate the extracellular matrix of different tissues for 3D cell cultures.inquiry BBM-3C-109 ECM Gel from Engelbreth-Holm-Swarm Murine Sarcoma ECM Gel From Engelbreth-Holm-Swarm Murine Sarcoma is prepared from Engelbreth-Holm-Swarm sarcoma in mice for 3D cell culture.inquiry BBM-3C-110 ECM Gel from Engelbreth-Holm-Swarm Murine Sarcoma ECM Gel From Engelbreth-Holm-Swarm Murine Sarcoma is prepared from Engelbreth-Holm-Swarm sarcoma in mice for 3D cell culture, without phenol red.inquiry BBM-3C-111 3D Cell Culture Gel solution 3D Cell Culture Gel Solution is a ready-to-use collagen solution that forms a solid gel by heating it to 37°C for cell culture.inquiry BBM-3C-112 3D RGD-CD Hydrogel Kits 3D Hydrogel Kits (Pre-Configured), a pre-configured 3D hydrogel system, consists of RGD (arginyl glycyl aspartate) degradable polymer and CD cell degradable cross-linking agent. When RGD and CD cross-linkers are mixed, they cross-link into a gel.inquiry BBM-3C-113 3D Hydrogel Kits (ECM) 3D Hydrogel Kits (ECM) is used to artificially create a three-dimensional (3D) cell culture environment. The kit consists of an extracellular matrix with a microporous structure from human sources.inquiry BBM-3C-114 3D PVA-PEG Hydrogel Kits 3D Hydrogel Kits (Pre-Configured), a pre-configured 3D hydrogel system, consists of maleimide-functionalized PVA and PEG non-cell-degradable crosslinker. When PVA polymer and CD cross-linkers are mixed, they cross-link into a gel.inquiry BBM-3C-115 3D Cell Culture Hydrogel Matrix 3D Cell Culture Hydrogel Matrix is a ready-to-use, xeno-free (animal source-free) functional hydrogel for 3D cell culture research.inquiry BBM-3C-116 3D Cell Culture Hydrogel Matrix Kit (RGD) 3D Cell Culture Hydrogel Matrix Kit (RGD) is a high-concentration, adjustable, xeno-free (animal source-free) hydrogel system. This system was modified with the cell adhesion peptide RGD to promote cell attachment and cell-matrix interactions during 3D cell culture.inquiry All of our products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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