Ace Therapeutics provides one-stop preclinical research and development services for sleep-wake disorders, covering the entire process from pathogenesis to drug screening and efficacy evaluation. Our services are designed to accelerate the drug discovery process for sleep-wake disorders and help clients advance innovative therapies from the laboratory to clinical trials.

Current Status of Drug Research for Sleep-Wake Disorders

The development of medications for sleep-wake disorders is a long and challenging task. Some drugs are available for the treatment of sleep-wake disorders, the most commonly used of which include sleeping pills and antidepressants. These drugs improve sleep quality and regulate wakefulness primarily by modulating neurotransmitter levels.

In terms of drug development, several pharmaceutical companies are investigating the development of new drugs to better treat sleep-wake disorders. Some of these drugs include novel sleeping pills and modulators such as PDE4 inhibitors. In addition, several pharmaceutical companies are investigating the development of gene-based drugs to better target individual gene expression profiles for the treatment of sleep-wake disorders.

How Can We Help?

Pathophysiology Research Services of Sleep-Wake Disorders

The neurobiology of sleep and wakefulness is complex, encompassing not only the arousal or sleep-promoting system, but also homeostasis, circadian rhythms, and motivational processes. The pathophysiology of sleep-wake disorders research service offered by Ace Therapeutics is designed to understand the mechanisms of the disorder and to provide theoretical support for the search for new treatments. Our experts integrate multidisciplinary research methods to investigate the pathophysiologic mechanisms of sleep-wake disorders. These approaches include the use of electrophysiological techniques, neuroimaging techniques to monitor brain activity and the application of genetic and molecular biology tools to identify key genes and proteins that affect sleep.

Preclinical Screening and Evaluation Services for Sleep-Wake Disorders Therapeutic Drugs

Ace Therapeutics provides clients with comprehensive preclinical screening and evaluation services for drugs for sleep-wake disorders. With a variety of neuroimaging techniques, physiological indicator monitoring techniques and behavioral tests, we can ensure efficient and accurate drug development. Our one-stop preclinical drug development services include the following:

• Rapidly identify compounds with potential therapeutic effects through our high-throughput screening platform.
• The effects of drug candidates on sleep patterns are meticulously evaluated through ex vivo and in vivo pharmacodynamic studies. Our approach includes the analysis of problems such as sleep rhythm disorders through polysomnographic techniques, and the use of behavioral and electrophysiological techniques to characterize body movement disorders and changes in neural activity in the brain.
• We conduct comprehensive toxicity and safety testing in animal models to ensure that our drug candidates are well tolerated and safe.

Our Advanced Technology and Preclinical Development Capabilities

Ace Therapeutics can provide insight into the pathophysiological mechanisms of sleep-wake disorders using a variety of neuroimaging techniques, physiological index monitoring techniques, and behavioral tests. Our preclinical imaging techniques include magnetic resonance imaging (MRI), computed tomography (CT), dual-energy X-ray absorptiometry (DXA), transmission electron microscopy (TEM), scanning electron microscopy (SEM), positron emission tomography (PET), single photon emission computed tomography (SPECT), functional ultrasound (fUS) imaging, functional near-infrared spectroscopy (fNIRS), which can be used to map the dynamic responses of brain networks in animal models.

In addition, our polysomnography techniques can be used to analyze problems such as sleep rhythm disorders, and our behavioral and electrophysiological techniques can be used to characterize physical movement disorders and changes in neural activity in the brain.

Related Services

• Animal Models in Psychiatry
• Behavior Tests in Psychiatry
• Magnetic resonance imaging (MRI) in Psychiatry
• Computed Tomography (CT) in Psychiatry
• Positron emission tomography (PET) in Psychiatry
• Electrophysiological Analysis in Psychiatry

Ace Therapeutics is committed to providing technical support for your understanding of the mechanisms and treatments for psychiatric disorders. We aim to help you develop safer, more effective, and more specific medications to provide better treatment for patients with sleep-wake disorders. If you are interested in our services, please contact us to learn how we can support you in your project.