For most psychiatric disorders, pathogenesis research as well as drug development revolves around the discovery and advancement of neurobiological mechanisms. Ace Therapeutics is a preclinical contract research organization for psychiatric disorders. Through our expertise and platform technologies, we help our clients explore the complex neurobiological mechanisms involved in psychiatric disorders. We are committed to translating this knowledge into new therapeutic targets, thereby enabling our clients to develop innovative and highly effective therapies for psychiatric disorders.

To achieve this goal, we employ a range of technologies, including cell and animal models, genome editing, molecular biology, molecular/cellular imaging, electrophysiology, high-throughput sequencing, etc. Our objective is to assist our clients in comprehensively examining the neurotransmitters, neural circuits, neurodevelopmental and neuroplasticity, neuroimmune networks, and neuronal activity involved in the onset and progression of psychiatric disorders.

Neurobiological Research Services We Offer for Psychiatric Disorders

Neurotransmitter Research Services

Neurotransmitters play an important role in the diagnosis and treatment of psychiatric disorders. Ace Therapeutics provides professional services and technical support to help clients gain insight into the role of neurotransmitters in psychiatric disorders. Our key services include:

• We will create precise animal models tailored to specific diseases to reveal the molecular mechanisms of neurotransmitter imbalance in psychiatric disorders.
• We utilize high-throughput sequencing, molecular biology techniques, electrophysiology, and neuroimaging to comprehensively assess neurotransmitter changes during the development of psychiatric disorders and their impact on the disease process.
• We offer neurotransmitter-based drug screening and target validation services to assist clients in discovering and developing novel therapeutics.

Neural Circuits Research Services

Ace Therapeutics combines animal models with neuroscience techniques such as optogenetics to study the neural circuits that mediate the onset of psychiatric disorders and to determine the direct causal relationship between psychiatric disorders and behavioral disorders by precisely intervening in these circuits. Our research team offers the following key services:

• The neurobiological features of psychiatric disorders are simulated in animal models, and the impact of neural circuit dysfunction on disease phenotypes is assessed by behavioral experiments.
• Combined with advanced brain imaging techniques to observe structural and functional changes in neural circuits.
• We also provide services such as gene expression analysis and neural network modeling to explain the link between neural circuits and psychiatric disorders at the molecular and systems level.

Neurodevelopmental & Neuroplasticity Research Services

The onset and progression of numerous psychiatric disorders are closely linked to abnormalities in neurodevelopment and neuroplasticity. This plasticity can occur at both the functional and structural levels, as well as at the synaptic, cellular, loop, and network levels. At Ace Therapeutics, we are committed to providing a comprehensive range of services to help our clients delve deeper into the neurobiological mechanisms of psychiatric disorders and facilitate scientific discovery and therapeutic development in this area.

• We use cellular models to study key factors such as neural stem cell differentiation and neuronal migration during neural development.
• We use animal models and imaging techniques to observe dynamic structural changes in neural circuits within the in vivo cortex at the cellular and synaptic levels and how these alterations affect the phenotype of psychiatric disorders.
• We also offer molecular biology techniques such as gene expression analysis and protein interaction studies to unravel the molecular mechanisms involved in neural development and plasticity.

Neuroimmune Mechanisms Research Services

Our objective is to provide our clients with a comprehensive solution to advance neuroimmunology research in psychiatric disorders. This includes, but is not limited to:

• Create animal models of mental illness and explore the interconnections between the immune system and psychiatric disorders.
• We assess the activity of cells involved in the development of psychiatric disorders, changes in inflammatory responses, and signaling pathways associated with psychiatric disorders through behavioral tests, tissue analysis techniques, molecular biology techniques, and immunological methods.

Neuronal Activity & Brain Imaging Research Services

Ace Therapeutics' experienced experts provide customized solutions based on the demands of our clients to help them delve into the abnormal neuronal activity associated with psychiatric disorders. Our research services include, but are not limited to, the following:

• Using rodents to create animal models of psychiatric disorders.
• Our advanced imaging and electrophysiological techniques enable us to assist our clients in studying neuronal firing patterns, synaptic transmission, neural network connectivity, and abnormal activity associated with psychiatric disorders.

Ace Therapeutics is dedicated to employing multidisciplinary technologies to assist clients in exploring the neurobiological mechanisms of psychiatric disorders from various vantages, thereby providing a theoretical foundation and innovative decisions for the preclinical therapeutic development of psychiatric disorders. If interested, please feel free to contact us. Our experienced team of experts will work closely with you to discuss the specifics of your project.

Related Services