Ace Therapeutics is a leading provider of neuroplasticity and neurodevelopmental solutions for psychiatric disorders. Our program-experienced team of experts is dedicated to offering tailored support in the early stages of psychiatric research.

Our Neuroplasticity Research Services of Psychiatric Disorders

Neuroplasticity is a crucial factor in the development and maintenance of brain functions, including learning and memory. It also plays a role in the recovery from brain injury and adaptation to environmental changes.

Fig. 1 Neuroplasticity processes in healthy development and in vulnerability to psychosis. (Vinogradov, S. et al., 2023)

To assist our clients in understanding the mechanisms of neuroplasticity related to psychiatric disorders, we provide the following services:

• Research on regulatory mechanisms of neuroplasticity: Explore the cellular signaling pathways, gene regulatory networks, and other molecular mechanisms that regulate neuroplasticity.
• Analysis of neuronal structural and functional plasticity: By employing cellular imaging, electrophysiology, and other techniques, we can gain a comprehensive understanding of the effects of different types of plasticity on brain structure and function.
• Research on the regulation of neurotransmitter system plasticity: Using animal models to study the regulatory role of neurotransmitters and their receptors in neuroplasticity to inform target discovery for the development of innovative therapies for psychiatric disorders.
• Research of the association between behavior and neuroplasticity: Our advanced animal models and behavioral testing capabilities enable our clients to explore the impact of neuroplasticity on behavioral change.

Our Neurodevelopmental Research Services of Psychiatric Disorders

Neurodevelopment is a highly coordinated process involving the proliferation, migration, differentiation, and maturation of neurons, as well as the formation and refinement of synaptic connections between them. Normal neurodevelopment is essential for the proper functioning of the nervous system, and any disruption in this process can lead to psychiatric disorders such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and schizophrenia.

To help our clients explore the neurodevelopmental mechanisms of psychiatric disorders, we offer the following services:

• Research on the molecular mechanisms of neurodevelopmental disorders: Using genome sequencing, proteomics, and other technologies to analyze the genetic and molecular biological factors that affect neurodevelopment and function.
• Cellular mechanisms of neurodevelopmental processes: Through neural stem cell differentiation, neuronal development, and other in vitro cellular models, we simulate the process of neural development, thus helping our clients to explore the cellular mechanisms of abnormal neural development.
• Research on the regulatory mechanism of neural development: Study the key genes affecting neural development, key regulatory factors, and their mechanisms of action.

Our Advanced Technologies

• Molecular biology techniques: Study of key genes and proteins in neuroplasticity and development using genomics, proteomics, CRISPR gene editing, RNA sequencing, protein blotting, and other techniques.
• Neuroimaging: Neuroimaging techniques such as Magnetic Resonance Imaging (MRI) and positron emission tomography (PET) are utilized to observe changes in brain structure and function.
• Customized cellular and animal models: Neuroplasticity and neurodevelopmental models are studied through customized in vivo and in vitro models.
• Behavioral assessment: We provide behavioral evidence for the pathophysiology of the disease through a series of behavioral tests.

The team of experts at Ace Therapeutics has extensive experience and expertise in the field of psychiatric disorders. We are committed to providing our clients with high-quality neurodevelopmental and neuroplasticity research services using advanced technologies and analytical methods to help you gain valuable insights into the diagnosis of psychiatric disorders and the development of therapies. Please contact us for more details and we will be happy to assist you.

References

1. Marzola, P., et al. Exploring the role of neuroplasticity in development, aging, and neurodegeneration. Brain Sciences. 13.12 (2023): 1610.
2. Vinogradov, S.; et al. Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity. Neuropsychopharmacology. 48.1 (2023): 168-185.

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