Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease, which may be caused by genes or the autoimmune system. The β-cells in patients have been damaged, clinically manifested as insulin secretion disorder, increased blood sugar and ketosis tendency.
As a dedicated CRO company, Ace Therapeutics offers a full range of services related to T1DM, in order to help you make progress on the discovery of new or modified medications, insulin alternatives or treatments.
T1DM occurs as a consequence of a breakdown in immune regulation, resulting in the expansion of autoreactive CD4+ and CD8+ T cells, autoantibody-producing B lymphocytes, and activation of the innate immune system that collaborate to destroy the insulin-producing β-cells.
Pathogenesis of T1DM (Desai, S., et al., 2021)
The discovery of insulin makes T1DM no longer an incurable disease and greatly improves the life expectancy and quality of life of T1DM patients. The β-cells in patients have been damaged, clinically manifested as insulin secretion disorder, increased blood sugar and ketosis tendency.
Diabetes is a field worthy of in-depth research, and experts and scholars in the field of diabetes have never stopped pursuing technological innovation. Ace Therapeutics provides research programs and technical services from pathology to preclinical.
Providing research services to study the genes, biochemical pathways related to diabetes at the molecular and cellular levels, and carry out integration and systematic analysis, which is helpful for the development of therapies.
Providing modeling service for T1DM study for understanding the mechanism and development of T1DM, as well as developing therapy and diagnosis for T1DM.
Providing a set of services including metabolomics-based biomarker development, β-cell stress and death biomarkers development and gut microbiota-based biomarker development.
We provide effective diagnostics development service based on different types of markers, that can help clients complete their disease model analysis more efficiently and help accelerate therapy development of T1DM.
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