Type 1 diabetes mellitus (T1DM) culminates in the autoimmune destruction of the pancreatic β-cells, leading to insufficient production of insulin and development of hyperglycemia. Diagnosis of diabetes can help researchers efficiently analyze the causes of diabetes and advance the development of therapies. Ace Therapeutics can provide diagnostic development service of T1DM with more efficient function analysis.
T1DM is a chronic autoimmune disease characterized by insulin deficiency as a consequence of autoimmune-mediated destruction of insulin producing pancreatic β-celIs. At the time of diagnosis, 80% to 90% of β-cells mass has been lost. Biomarkers including a combination of glucose, glycated molecules, C-peptide, and autoantibodies have been well established for the diagnosis of T1DM.
Pancreatic Changes and Immune Abnormalities in T1DM (Alvin, C. P. The Journal of Clinical Investigation. 2021)
Although T1DM has been investigated for over a century, the etiology of the disease is still not fully understood. Until now, the biomarkers implemented in clinical practice such as glucose, HbAlc, C-peptide, and autoantibodies (AAb) were mainly diagnostic markers.
The Many Types of Potential Biomarkers (Yi, L.; et al. Translational Research. 2018)
T1DM is distinguished from other types by a blood test for the presence of autoantibodies that target various components of the β-cell. The most commonly available tests detect antibodies against glutamic acid decarboxylase, the β-cell cytoplasm, or insulin. Islet cell antibodies can be measured by conventional immunofluorescence, while the other antibodies can be measured by radioactive binding assay.
Different Types of Potential Biomarkers for T1DM and the Associated Omics Technologies (Yi, L.; et al. Translational Research. 2018)
Effective diagnostics can help clients complete their disease model analysis more efficiently and help accelerate therapy development of T1DM. Ace Therapeutics can provide the T1DM diagnostic development services for different diagnostic markers (glucose, HbAlc, C-peptide, autoantibodies, proteins, nucleic acids, and metabolites, et al.).
In addition, we provide T1DM biomarker development and T1DM therapy development service for our clients worldwide.
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Ace Therapeutics offers cost-effect and high-quality research services related to T1DM diagnostic development for our clients worldwide. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us .
