In Vivo Modeling of Diabetes Complications

Complications of diabetes trouble people much more than diabetes itself, so it's very important to construct related animal models for diagnosis, prevention, and treatment of disease. Ace Therapeutics can develop different animal models of diabetes complications and provide valuable preclinical tools in research and evaluation for new drugs in treating a series of diabetes complications.

What are Diabetes Complications?

Vasculopathy develops over time in the tissues and organs of patients with DM, commonly including the heart, brain, kidneys, retina, foot, and nerves. These changes give rise to their respective chronic complications. The most common chronic complications considered as related to diabetes include microvascular disease and macrovascular diseases. Extensive epidemiological studies have consistently demonstrated that the duration of diabetes is positively related to the development of complications. Besides, there are more disabilities and deaths due to the complications arising from diabetes than from diabetes itself.

Fig 1. Complications associated with type 2 diabetes. Fig. 1. Secondary complications associated with T2DM. (Blahova J, et al., 2021)

Our Diabetes Complications Modeling Services

Ace Therapeutics offers clients a comprehensive range of model development services for diabetic complications, including diabetic nephropathy, diabetic peripheral neuropathy, and other complications. Our models can be used for mechanistic studies, drug screening, and pharmacodynamic evaluation of diabetic complications. Our customized animal model development services meet the specific project needs of our clients.

In Vivo Modeling of Diabetic Wound
Ace Therapeutics provides animal model development services for diabetic wounds, our build methodology involves the creation of controlled wounds in diabetic animal models and healing progress monitoring to provide comprehensive data.
In Vivo Modeling of Diabetic Nephropathy
We provide animal model development services for diabetic nephropathy, and our models can be well used to study the pathogenesis of kidney injury, including glomerular dysfunction, inflammation, and fibrosis studies.
In Vivo Modeling of Diabetic Atherosclerosis
We also offer animal model development services for diabetic atherosclerosis, using our models to gain insight into underlying inflammatory processes and vascular dysfunction.
In Vivo Modeling of Diabetic Cataract
We provide diabetic cataract animal model development services to help clients study the association between diabetes and cataract formation and cataract-related drug testing.
In Vivo Modeling of Diabetic Retinopathy
We offer diabetic retinopathy model development services for studying pathological changes in the retina such as vascular leakage and retinal cell death.
In Vivo Modeling of Diabetic Neuropathy
We provide diabetic neuropathy model development services to our clients to study the pathogenesis of diabetic neuropathy and drug testing.

Our Analysis Services for Diabetes Complications Research

To assist customers in evaluating the efficacy of drugs using animal models of diabetes complications, we provide comprehensive analytical services.

Body composition analysis
Tissue & blood collections
Serum cholesterol/HDL/LDL/FFA
Serum biochemistry
Histopathological evaluation
Immunohistochemistry analysis
Behavioral tests (Von Frey test, Hindpaw withdrawal test, Tail-flip test, etc.)

For more information on how we can tailor our services to your specific needs, don't hesitate to contact us. In partnership with Ace Therapeutics, access to innovative models and expert support powers the diabetes complications research.

Reference

Blahova J, et al. (2021) Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus. Pharmaceuticals. 14(8): 806.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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