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The treatment of diabetic wounds (DW) has always been a challenge for the medical community due to their multifaceted pathophysiology. Ace Therapeutics is committed to helping our clients develop a variety of animal models of DW, such as the excisional wound splinting model, to study the complex cellular and biochemical processes involved in skin repair in DW healing and to evaluate drug efficacy.
Wound healing is a complex process consisting of four phases: hemostasis, inflammation, proliferation, and remodeling. Appropriate interactions between these different stages are critical for adequate and successful wound healing to maintain the normal structural and functional integrity of the skin. Wound healing in humans is related to physiology, age, gender, disease status, and other factors. Diabetes mellitus (DM) is one such disease that leads to multiple complications, of which DW is considered the most common and devastating. Studying the molecular mechanisms involved in this process is crucial for discovering new therapeutic approaches that promote healing.
Fig. 1. Pathophysiology of diabetic wounds. (Burgess J L, et al., 2021)
At Ace Therapeutics, we employ a variety of animal species for modeling in the field of DW healing research, including rodents and large mammals (dogs, pigs, and primates). Given some of the characteristics associated with humans, such as genetic, biological, and behavioral similarities, as well as economy and ease of handling, we recommend that our clients choose rodents such as c57 mice, db/db mice, and rats as animal models for DW research. We mainly provide DW modeling for the following species:
| Animal Species | Advantages |
|---|---|
| Mouse |
|
| Rat |
|
| Rabbit |
|
| Guinea pig |
|
We induce DW in animals through two phases, including diabetes induction and wound induction. We typically use streptozotocin and alloxan to induce diabetes and induce DW by cutting, radiation, burning, etc. We provide a comprehensive selection of animal models for DW that simulate human pathological conditions.
| Wound Type | Methods | Applications |
|---|---|---|
| Full-thickness excision wound model in rodents | A wound is created by damaging all the layers of the skin. | Pharmacological evaluation of newer entities and formulations. |
| Incision wound model in rodents | A longitudinal incision of 4 - 6 cm is made. | Research on the quality of healed skin tissue by checking tensile strength. |
| Burn wound model in rodents | Burns are created by hot wax/ steam/ hot air/ heated brass rods. | Research on the healing process of burn wounds in patients with diabetes. |
| Ischemic ear wound model in rabbit | Ligation of blood vessels creates an ischemic region in which wounds can be created. | Examination of various specialists amid ischemic conditions with impaired wound healing. |
| Tape striping wound model in rodents | Only the stratum corneum is removed using adhesive tape. | Evaluation of reepithelization and adhesive wound dressing nature. |
| Infected wound model | Specific organisms or a group of organisms are inoculated on the wound. | Research on the relationship between host and pathogen. Research on the immune response to infection during the DW healing process. |
| Excision wound splint model | Splints are used to prevent the skin from shrinking to heal and to ensure healing through granulation tissue deposition and epithelialization. | Research on the process of granulation and epithelial re-formation. Visualize and record changes in wound closure, granulation, and vascular system during the DW healing process. |
Contact us today to learn more about our modeling services for DW and how we can collaborate to advance your research goals!
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
