A thrombotic stroke is a specific type of ischemic stroke, caused primarily by plaque buildup in the large arteries that supply blood to the brain. When a clot or fatty deposit, known as a thrombus, significantly obstructs blood flow, the brain is deprived of essential oxygen and nutrients, ultimately resulting in a stroke.
High-quality preclinical research and therapeutic development are critical to overcoming the challenges of thrombotic stroke. Ace Therapeutics excels in this area to help you discover the next breakthrough in therapeutics for thrombotic stroke.
Ace Therapeutics provides animal models that mimic the natural occurrence and pathology of thrombotic stroke. We can help our clients develop anti-thrombotic drugs for stroke and evaluate their therapeutic efficacy and safety using a variety of approaches, such as our industry-leading brain imaging capabilities.
We can construct thrombotic stroke models by intravenously injecting a photosensitizing dye (e.g., Rose Bengal) and then shining a focused beam of light into the brain. This model allows us to help clients study the cellular and molecular mechanisms of ischemic stroke, test functional/cognitive outcomes, identify important biomarkers, and evaluate the efficacy of new therapeutics.
We can induce autologous thrombosis by local microinjection of purified mouse thrombin into the middle cerebral artery (MCA) of mice. We continuously monitor cerebral blood flow throughout the procedure using laser Doppler flowmetry.
Our scientists are dedicated to assisting clients in studying the effects of potential neuroprotective and thrombolytic therapies through a controlled and consistent approach using mouse models of in situ thromboembolic stroke.
With our extensive experience and expertise in drug discovery, we can assist our clients in discovering new targets and developing novel therapies for thrombotic stroke.
We offer comprehensive preclinical thrombotic stroke research services for pharmaceutical companies. Our goal is to support these companies in the development of innovative therapeutics designed to dissolve or remove clots that cause strokes.
| Preclinical Evaluation Services | Service Details |
|---|---|
| Measurement of physiological parameters in animal models of thrombotic stroke | Measure physiological parameters (body temperature, pH, pCO2, and pO2) in animals before and after in situ thromboembolic clot formation. |
| Observation of clot formation in animal models of thrombotic stroke | Provide photomicrographs of various surgical stages to visualize clot formation in animals after thrombin injection. |
| Histological analysis services for thrombotic stroke therapy development | Stain coronal brain sections taken from occluded animals after thrombin injection to determine the histological features of the clots formed. |
| Cerebral blood flow monitoring services in animal models of thrombotic stroke | Measure cerebral blood velocity during thrombin-induced in situ clot formation and the recovery of cerebral blood velocity after drug treatment using laser Doppler ultrasound. |
| Measurement of infarct volumes in animal models of thrombotic stroke | Measure infarct volume before and after drug administration in animal models of thrombotic stroke. |
| Evaluation of neurological deficits and functional recovery | Assess changes in sensorimotor and cognitive function before and after drug administration in animal models of thrombotic stroke using modified neurological severity scores and behavioral tests. |
Whether you're seeking a foundational study to start your research or advanced preclinical studies on thrombotic stroke, Ace Therapeutics is dedicated to delivering the highest quality results to ensure that your program progresses smoothly. If you are interested in our services, please contact us for more information.
Ace Therapeutics is a global leading provider of stroke research services. We are committed to accelerating progress in stroke research and drug development.